A COMPARATIVE STUDY ON THE ANTICONVULSIVE EFFECTS OF THE AQUEOUS EXTRACT OF THE ROSMARINUS OFFICINALIS PLANT WITH PHENOBARBITAL IN PENTYLENTETRAZOL-INDUCED SEIZURES IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BOROUSHAKI M.T.; BAHARLOO A.; MALEK F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2002 | Volume:3 | Issue:1-2 Page(s): 53-58

Download Full-Text

Persian Verion

View:

642

Download:

Cites:

Information Journal Paper

Title

A COMPARATIVE STUDY ON THE ANTICONVULSIVE EFFECTS OF THE AQUEOUS EXTRACT OF THE ROSMARINUS OFFICINALIS PLANT WITH PHENOBARBITAL IN PENTYLENTETRAZOL-INDUCED SEIZURES IN MICE

Author(s)

BOROUSHAKI M.T. | BAHARLOO A. | MALEK F. | Issue Writer Certificate

Keywords

ROSMARINUS OFFICINALISQ4

PENTYLENTETRAZOLQ2

PHENOBARBITALQ3

SEIZUREQ3

Abstract

Introduction: The convulsive disorders are among chronic diseases, which usually need a long-term drug therapy. Unfortunately, most of the drugs used clinically to treat disorders exert many side effects. Therefore, search for finding new drugs is being carried out in many laboratories. The object of this research is a comparative study on the anticonvulsive effect of the aqueous extract of the plant ROSMARINUS OFFICINALIS with PHENOBARBITAL in pentylenetetrazol-induced SEIZUREs in mice.Materials and Methods: After acclimatization, animals were randomly divided in different groups. Control group received normal saline (6 ml/kg), standard groups received (10, 20, 30 and 40 mg/kg) PHENOBARBITAL and the test groups received aqueous plant extract (3, 6, 9 and 12 ml/kg). All injections were carried out as i.p. All animals were firstly exposed to PENTYLENTETRAZOL (80 mg/kg, i.p). The onset of SEIZUREs, behavioral changes, duration of the SEIZUREs and number of death were recorded in all groups during the first 24 hours.Results:Results showed that all amounts of the plant extracts delay the onset of SEIZUREs but the most effective dose was 12 ml/kg, which was comparable to PHENOBARBITAL (30 mg/kg). All amount of the extract, except 3 ml/kg, significantly reduced the duration of SEIZUREs, compared to the control group. Number of death was 45, 0 and 10 percent in control, standard and test group; respectively.Conclusion: Findings showed that 12 ml/kg of the aqueous plant extract is able to reduce the onset of SEIZUREs, duration of SEIZUREs and number of death after 24 hours in PENTYLENTETRAZOL-induced SEIZUREs.

Cites

No record.

References

No record.

Cite

APA: Copy

BOROUSHAKI, M.T., BAHARLOO, A., & MALEK, F.. (2002). A COMPARATIVE STUDY ON THE ANTICONVULSIVE EFFECTS OF THE AQUEOUS EXTRACT OF THE ROSMARINUS OFFICINALIS PLANT WITH PHENOBARBITAL IN PENTYLENTETRAZOL-INDUCED SEIZURES IN MICE. KOOMESH, 3(1-2), 53-58. SID. https://sid.ir/paper/37447/en

Vancouver: Copy

BOROUSHAKI M.T., BAHARLOO A., MALEK F.. A COMPARATIVE STUDY ON THE ANTICONVULSIVE EFFECTS OF THE AQUEOUS EXTRACT OF THE ROSMARINUS OFFICINALIS PLANT WITH PHENOBARBITAL IN PENTYLENTETRAZOL-INDUCED SEIZURES IN MICE. KOOMESH[Internet]. 2002;3(1-2):53-58. Available from: https://sid.ir/paper/37447/en

IEEE: Copy

M.T. BOROUSHAKI, A. BAHARLOO, and F. MALEK, “A COMPARATIVE STUDY ON THE ANTICONVULSIVE EFFECTS OF THE AQUEOUS EXTRACT OF THE ROSMARINUS OFFICINALIS PLANT WITH PHENOBARBITAL IN PENTYLENTETRAZOL-INDUCED SEIZURES IN MICE,” KOOMESH, vol. 3, no. 1-2, pp. 53–58, 2002, [Online]. Available: https://sid.ir/paper/37447/en

Related Journal Papers