EFFECT OF INTRA-PERIRHINAL INJECTION OF 2-CHLOROADENOSINE ON AMYGDALOID KINDLED SEIZURES IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

PALIZVAN M.R.; POURGHOLAMI M.H.; MIRNAJAFIZADEH S.J.; ROSTAMPOUR VAJARGAH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2001 | Volume:2 | Issue:2 Page(s): 95-103

Download Full-Text

Persian Verion

View:

572

Download:

Cites:

Information Journal Paper

Title

EFFECT OF INTRA-PERIRHINAL INJECTION OF 2-CHLOROADENOSINE ON AMYGDALOID KINDLED SEIZURES IN RATS

Author(s)

PALIZVAN M.R. | POURGHOLAMI M.H. | MIRNAJAFIZADEH S.J. | ROSTAMPOUR VAJARGAH M. | Issue Writer Certificate

Keywords

SEIZUREQ3

2-CHLOROADENOSINEQ2

CAFFEINEEQ3

AMYGDALAQ3

PERIRHINAL CORTEXQ4

Abstract

Introduction: Adenosine is a neuromodulator which has anticonvulsant effects in different laboratory models of epilepsy including kindling, but the precise site (S) of its action in the brain has not been recognized. In this study, possible anticonvulsant effects of 2-CHLOROADENOSINE injected locally into the PERIRHINAL CORTEX of AMYGDALA kindled rats was investigated. Materials and Methods: Animals were kindled by daily electrical stimulation. Full amygdale rast were microinfused ( 1µl/ 4min) with 2-CHLOROADENOSINE ( 2-CLA; 5, 10, 15, 25 and 100nM), caffeine (50 and 100µm) or artificial cerebrospinal fluid applied through a guide cannula located in the PERIRHINAL CORTEX and were stimulated at 10, 30 and 120 min post drug injection. Results: At the doses employed, 2-CLA significantly reduced after discharge duration and stage 5 SEIZURE duration. The latency to stage 4 SEIZURE was increased only at the highest dose of 2-CLA (100 nM), while even at this dose no significant change in SEIZURE stage could be seen. The maximum effect of 2-CLA was obtained 30 min after microinjection of the drug. Pretreatment (intra perirhinal) of animals with the nonselective adenosine antagonist, caffeine (50 µm; 1 µl), blocked the anticonvulsant activity of 2-CLA. Conclusion: These results suggest that adenosine receptors located in the PERIRHINAL CORTEX may play an important role in the suppression of SEIZURE activity elicited from the AMYGDALA.

Cites

No record.

References

No record.

Cite

APA: Copy

PALIZVAN, M.R., POURGHOLAMI, M.H., MIRNAJAFIZADEH, S.J., & ROSTAMPOUR VAJARGAH, M.. (2001). EFFECT OF INTRA-PERIRHINAL INJECTION OF 2-CHLOROADENOSINE ON AMYGDALOID KINDLED SEIZURES IN RATS. KOOMESH, 2(2), 95-103. SID. https://sid.ir/paper/37543/en

Vancouver: Copy

PALIZVAN M.R., POURGHOLAMI M.H., MIRNAJAFIZADEH S.J., ROSTAMPOUR VAJARGAH M.. EFFECT OF INTRA-PERIRHINAL INJECTION OF 2-CHLOROADENOSINE ON AMYGDALOID KINDLED SEIZURES IN RATS. KOOMESH[Internet]. 2001;2(2):95-103. Available from: https://sid.ir/paper/37543/en

IEEE: Copy

M.R. PALIZVAN, M.H. POURGHOLAMI, S.J. MIRNAJAFIZADEH, and M. ROSTAMPOUR VAJARGAH, “EFFECT OF INTRA-PERIRHINAL INJECTION OF 2-CHLOROADENOSINE ON AMYGDALOID KINDLED SEIZURES IN RATS,” KOOMESH, vol. 2, no. 2, pp. 95–103, 2001, [Online]. Available: https://sid.ir/paper/37543/en

Related Journal Papers