Preventive effect six weeks of swimming training on the levels of cytokines and brain-derived neurotrophic rat model of EAE

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Hosseini Sayed Mojtaba; FALLAH MOHAMMADI ZIA; Talebi Vahid

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Journal: Journal of Sport Biosciences Year:2020 | Volume:12 | Issue:1 Page(s): 53-65

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Title

Preventive effect six weeks of swimming training on the levels of cytokines and brain-derived neurotrophic rat model of EAE

Author(s)

Hosseini Sayed Mojtaba | FALLAH MOHAMMADI ZIA | Talebi Vahid | Issue Writer Certificate

Keywords

Experimental autoimmune encephalomyelitisQ1

Lewis ratsQ1

swimming trainingQ1

cytokineQ1

Abstract

Multiple sclerosis is a progressive and chronic autoimmune disease of the central nervous system that is associated with the destruction of the myelin sheath of nerve cells. The aim of this study was to investigate the preventive effect of six weeks of forced swimming on the levels of TNF-α , IL-10 and BDNF is the EAE model rats. Twenty-five female Lewis were divided into five groups: healthy control, MS control, healthy swimming, MS swimming, and solvent. swimming training for 6 weeks and 5 days a week. swimming training program began with 30 minutes daily five-minute period in the second week with an increase to 60 minutes. Overload training was set by adjusting the power and speed of the water while swimming. Also, EAE was induced model at the end of the sixth week of training and After 14 days’ mice were sacrificed. Right Cerebral hemisphere for the histology and right Cerebral hemisphere was transferred to the lab for analysis of protein measurements. Swimming exercise in rats EAE model leads to a significant reduction in TNF-α (P=0/001) and no significant change in IL-10 (P=0/71) and BDNF (P=0/70) was. In rats trained clinical signs appeared delayed. Furthermore, results of histological staining showed that certain differences were observed between trained and untrained. EAE-induced demyelination model increases the damage to brain tissue Shows that swimming exercise intensity and duration of six weeks can be effective in delaying symptoms, although these symptoms are delayed in the short term.

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APA: Copy

Hosseini, Sayed Mojtaba, FALLAH MOHAMMADI, ZIA, & Talebi, Vahid. (2020). Preventive effect six weeks of swimming training on the levels of cytokines and brain-derived neurotrophic rat model of EAE. SPORT BIOSCIENCES (HARAKAT), 12(1 ), 53-65. SID. https://sid.ir/paper/376919/en

Vancouver: Copy

Hosseini Sayed Mojtaba, FALLAH MOHAMMADI ZIA, Talebi Vahid. Preventive effect six weeks of swimming training on the levels of cytokines and brain-derived neurotrophic rat model of EAE. SPORT BIOSCIENCES (HARAKAT)[Internet]. 2020;12(1 ):53-65. Available from: https://sid.ir/paper/376919/en

IEEE: Copy

Sayed Mojtaba Hosseini, ZIA FALLAH MOHAMMADI, and Vahid Talebi, “Preventive effect six weeks of swimming training on the levels of cytokines and brain-derived neurotrophic rat model of EAE,” SPORT BIOSCIENCES (HARAKAT), vol. 12, no. 1 , pp. 53–65, 2020, [Online]. Available: https://sid.ir/paper/376919/en

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