THE EFFECT OF PLASMA TESTOSTERON ON EPILEPTIFORM SEIZURES INDUCED BY PENTYLEN TETRAZOLE (PTZ ) IN NORMAL AND GONADECTOMIZED MALE RATS

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JAJVANDIAN R.; BARAHOOII MOGHADAM N.M.; MOGHIMI A.; BEHNAM RASOULI MORTEZA

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Journal: Armaghane Danesh Year:2005 | Volume:10 | Issue:37 Page(s): 17-27

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Title

THE EFFECT OF PLASMA TESTOSTERON ON EPILEPTIFORM SEIZURES INDUCED BY PENTYLEN TETRAZOLE (PTZ ) IN NORMAL AND GONADECTOMIZED MALE RATS

Author(s)

JAJVANDIAN R. | BARAHOOII MOGHADAM N.M. | MOGHIMI A. | BEHNAM RASOULI MORTEZA | Issue Writer Certificate

Keywords

EPILEPSYQ2

ANDROGENEQ3

TESTOSTERONQ2

PENTYLENTETRAZOLEQ2

RATQ2

Abstract

Introduction & Objective: It has been verified that ANDROGENE concentration in epileptic men who were treated with antiepileptic drugs is decreased and this results in a decrease in sexual activities in such patients. Although there are many investigations regarding the effects of antileptic drugs on the RATe of serum ANDROGENEs and particularly TESTOSTERON, little is known about the probable effects of ANDROGENEs on epileptic seizures. In this study the effects of plasma level of TESTOSTERON on epileptiform seizures in three cases (normal, increased and decreased) induced with PENTYLENTETRAZOLE (PTZ) in Wistar male RATs were investigated. Materials & Methods: Wistar male RATs with similar response and sensitivity to PTZ and epileptiform seizures were randomly assigned to the five following: groups (n=8 for each group). 1st exprimental group: Intramuscular injection of TESTOSTERON (5 mg/Kg BW) and after 2 hours intraperitoneal injection of PTZ (25mg/Kg BW/for max. 3 times); 2nd experimental group: treatment with TESTOSTERON (0.5 mg/Kg BW) for 10 days and injections of PTZ thereafter; control group for 1st & 2nd experimental RATs where they received sesame oil and then PTZ in a protocol precisely similar to the 1st and 2nd groups; 3rd exprimental group PTZ injections and recording of epileptiform convulsions before gonadectomy (as control) and repeat of PTZ injections after 10 days. The last protocol was performed in two groups: gonadectomized, without any TESTOSTERON injections, and gonadectomized but with one dose of testoteron. Results:The results show that increase in serum TESTOSTERON level does not affect epileptiform convulsions, whereas the reduction of TESTOSTERON level increasesthe partial seizures (p<0.001) and duration of tonic-clonic seizures (p<0.05). Conclusion: Results of this study show that TESTOSTERON has an anticonvulsant effect and this effect might be through neurosteroid metabolites, where these metabolites affect on GASA A receptor complex.

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APA: Copy

JAJVANDIAN, R., BARAHOOII MOGHADAM, N.M., MOGHIMI, A., & BEHNAM RASOULI, MORTEZA. (2005). THE EFFECT OF PLASMA TESTOSTERON ON EPILEPTIFORM SEIZURES INDUCED BY PENTYLEN TETRAZOLE (PTZ ) IN NORMAL AND GONADECTOMIZED MALE RATS. ARMAGHAN DANESH, 10(37), 17-27. SID. https://sid.ir/paper/377488/en

Vancouver: Copy

JAJVANDIAN R., BARAHOOII MOGHADAM N.M., MOGHIMI A., BEHNAM RASOULI MORTEZA. THE EFFECT OF PLASMA TESTOSTERON ON EPILEPTIFORM SEIZURES INDUCED BY PENTYLEN TETRAZOLE (PTZ ) IN NORMAL AND GONADECTOMIZED MALE RATS. ARMAGHAN DANESH[Internet]. 2005;10(37):17-27. Available from: https://sid.ir/paper/377488/en

IEEE: Copy

R. JAJVANDIAN, N.M. BARAHOOII MOGHADAM, A. MOGHIMI, and MORTEZA BEHNAM RASOULI, “THE EFFECT OF PLASMA TESTOSTERON ON EPILEPTIFORM SEIZURES INDUCED BY PENTYLEN TETRAZOLE (PTZ ) IN NORMAL AND GONADECTOMIZED MALE RATS,” ARMAGHAN DANESH, vol. 10, no. 37, pp. 17–27, 2005, [Online]. Available: https://sid.ir/paper/377488/en

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