Effect of Artemisia ciniformis Extract on Expression of NorA Efflux Pump Gene in Ciprofloxacin Resistant Staphylococcus aureus by Real Time PCR

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Ghomi Zeynab; TAFVIZI FARZANEH; NASEH VAHID; Akbarzadeh Iman

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2020 | Volume:14 | Issue:1 Page(s): 55-69

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Information Journal Paper

Title

Effect of Artemisia ciniformis Extract on Expression of NorA Efflux Pump Gene in Ciprofloxacin Resistant Staphylococcus aureus by Real Time PCR

Author(s)

Ghomi Zeynab | TAFVIZI FARZANEH | NASEH VAHID | Akbarzadeh Iman | Issue Writer Certificate

Keywords

Staphylococcus aureusQ2

CiprofloxacinQ2

norAQ1

Efflux PumpQ1

Artemisia ciniformisQ1

Abstract

Background: Activity of norA Efflux Pump is one of the antibiotic resistance mechanisms in Ciprofloxacin resistant Staphylococcus aureus. In this study, the effect of Artemisia ciniformis extract on reducing the expression of norA Efflux Pumps gene in Ciprofloxacin-resistant Staphylococcus aureus isolates was studied. Materials & Methods: Ciprofloxacin resistant S. aureus isolates, were treated by different concentration of A. ciniformis extract. After extracting RNA and synthesizing cDNA, norA Efflux Pump expression was evaluated by Real Time PCR. Results: There was significant decrease of norA Efflux Pump expression in Ciprofloxacin-resistant S. aureus isolates treated by A. ciniformis extract (P<0. 05). Also, a different expression of norA Efflux Pump gene was reported. Conclusion: It seems A. ciniformis extract as a natural inhibitor, had potential for suppression of norA Efflux Pump activity.

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APA: Copy

Ghomi, Zeynab, TAFVIZI, FARZANEH, NASEH, VAHID, & Akbarzadeh, Iman. (2020). Effect of Artemisia ciniformis Extract on Expression of NorA Efflux Pump Gene in Ciprofloxacin Resistant Staphylococcus aureus by Real Time PCR. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 14(1 ), 55-69. SID. https://sid.ir/paper/377749/en

Vancouver: Copy

Ghomi Zeynab, TAFVIZI FARZANEH, NASEH VAHID, Akbarzadeh Iman. Effect of Artemisia ciniformis Extract on Expression of NorA Efflux Pump Gene in Ciprofloxacin Resistant Staphylococcus aureus by Real Time PCR. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2020;14(1 ):55-69. Available from: https://sid.ir/paper/377749/en

IEEE: Copy

Zeynab Ghomi, FARZANEH TAFVIZI, VAHID NASEH, and Iman Akbarzadeh, “Effect of Artemisia ciniformis Extract on Expression of NorA Efflux Pump Gene in Ciprofloxacin Resistant Staphylococcus aureus by Real Time PCR,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 14, no. 1 , pp. 55–69, 2020, [Online]. Available: https://sid.ir/paper/377749/en

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