The Evaluation of the Level of C3 and C4 Complements in Unstimulated Saliva of Patients with Oral Lichen Planus

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ROHANI BITA; MIRZAII DIZGAH MOHAMMAD HOSSEIN; MIRZAII DIZGAH IRAJ

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2020 | Volume:14 | Issue:3 Page(s): 19-25

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Title

The Evaluation of the Level of C3 and C4 Complements in Unstimulated Saliva of Patients with Oral Lichen Planus

Author(s)

ROHANI BITA | MIRZAII DIZGAH MOHAMMAD HOSSEIN | MIRZAII DIZGAH IRAJ | Issue Writer Certificate

Keywords

Complement C3Q1

Complement C4Q1

Lichen planusQ1

OralQ3

SalivaQ3

Abstract

Background and Objectives: Deficiency in the complement system can lead to some autoimmune diseases, such as systemic lupus erythematosus. The purpose of this study was to investigate the levels of C3 and C4 complements in unstimulated Saliva of individuals with Oral Lichen planus (OLP) and healthy subjects. Methods: In this case-control study, 31 healthy individuals and 31 patients with OLP entered the study. The values of C3 and C4, were measured using immunoturbidimetric method, and statistical analysis of data was carried out by t-and ROC tests. Results: The mean concentrations of C3 and C4 in unstimulated Saliva in patients with OLP, were significantly lower than the control group. The C4 cut-off point was obtained to distinguish patients from healthy individuals, 0. 78 mg/dL with a sensitivity of 76 and a specificity of 55. Conclusion: The levels of C3 and C4 complement proteins were low in OLP. Therefore, it seems that these complements are involved in the pathogenesis of OLP and may be considered as potential biological markers for the diagnosis of OLP.

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APA: Copy

ROHANI, BITA, MIRZAII DIZGAH, MOHAMMAD HOSSEIN, & MIRZAII DIZGAH, IRAJ. (2020). The Evaluation of the Level of C3 and C4 Complements in Unstimulated Saliva of Patients with Oral Lichen Planus. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 14(3 ), 19-25. SID. https://sid.ir/paper/379697/en

Vancouver: Copy

ROHANI BITA, MIRZAII DIZGAH MOHAMMAD HOSSEIN, MIRZAII DIZGAH IRAJ. The Evaluation of the Level of C3 and C4 Complements in Unstimulated Saliva of Patients with Oral Lichen Planus. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2020;14(3 ):19-25. Available from: https://sid.ir/paper/379697/en

IEEE: Copy

BITA ROHANI, MOHAMMAD HOSSEIN MIRZAII DIZGAH, and IRAJ MIRZAII DIZGAH, “The Evaluation of the Level of C3 and C4 Complements in Unstimulated Saliva of Patients with Oral Lichen Planus,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 14, no. 3 , pp. 19–25, 2020, [Online]. Available: https://sid.ir/paper/379697/en

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