Effect of Arnebia Euchroma Root Ointment on Surgical Wound Healing in Wistar Rats

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RAFIEI MOHAMMAD HOSSEIN; Jafarzadeh Hamed; Mollaei Aghil; NASIRI EBRAHIM

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:30 | Issue:187 Page(s): 28-37

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Title

Effect of Arnebia Euchroma Root Ointment on Surgical Wound Healing in Wistar Rats

Author(s)

RAFIEI MOHAMMAD HOSSEIN | Jafarzadeh Hamed | Mollaei Aghil | NASIRI EBRAHIM | Issue Writer Certificate

Keywords

Arnebia euchromaQ1

woundQ2

healingQ2

Wistar ratsQ1

herbal medicineQ3

Abstract

Background and purpose: post-operative surgical wound healing is highly important, so, it could be of great benefit to find suitable alternatives for chemical drugs through herbal remedies in Persian Medicine. The purpose of this study was to determine the effect of Arnebia euchroma ointment on surgical wound healing process. Materials and methods: In this experimental study, 24 Wistar rats were randomly divided into four groups (n=6 per group); controls (no intervention), positive controls (silver sulfadiazine cream 1%), intervention group I (Arnebia euchroma ointment), and intervention group II (mixed Arnebia euchroma and silver sulfadiazin cream1%). In all groups, an ulcer was developed in the back of the neck, then the groups were treated for 21 days. wound healing was evaluated at days 4, 7, 14, and 21. Data were analyzed in SPSS V22 applying one-way ANOVA and Games-Howell post hoc test for normal distribution and Kruskal-Wallis test for non-normal distribution. Results: Surgical wound healing was found be significantly different between intervention group I and control group at days 4 (P= 0. 00) and 7 (P= 0. 02). Percentage of wound healing at day 14, in control group, the positive controls, and intervention groups I and II were 81. 16± 4. 4, 84± 19. 27, 94. 28± 4 and 82. 20± 19, respectively. The rate was considerably higher in intervention group I (P= 0. 07). Conclusion: Topical use of Arnebia euchroma root ointment can facilitate surgical wound healing.

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APA: Copy

RAFIEI, MOHAMMAD HOSSEIN, Jafarzadeh, Hamed, Mollaei, Aghil, & NASIRI, EBRAHIM. (2020). Effect of Arnebia Euchroma Root Ointment on Surgical Wound Healing in Wistar Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(187 ), 28-37. SID. https://sid.ir/paper/380167/en

Vancouver: Copy

RAFIEI MOHAMMAD HOSSEIN, Jafarzadeh Hamed, Mollaei Aghil, NASIRI EBRAHIM. Effect of Arnebia Euchroma Root Ointment on Surgical Wound Healing in Wistar Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(187 ):28-37. Available from: https://sid.ir/paper/380167/en

IEEE: Copy

MOHAMMAD HOSSEIN RAFIEI, Hamed Jafarzadeh, Aghil Mollaei, and EBRAHIM NASIRI, “Effect of Arnebia Euchroma Root Ointment on Surgical Wound Healing in Wistar Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 187 , pp. 28–37, 2020, [Online]. Available: https://sid.ir/paper/380167/en

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