The effect of interval training and selenium nanoparticles on mTOR and LC3 mRNA expression in mice bearing breast cancer

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RANJBAR KIA; AGHA ALINEJAD HAMID; SHAHBAZI SHIRIN; Molanori Shamsi Mahdieh

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Journal: Journal of Sport Biosciences Year:2018 | Volume:10 | Issue:2 Page(s): 177-192

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Title

The effect of interval training and selenium nanoparticles on mTOR and LC3 mRNA expression in mice bearing breast cancer

Author(s)

RANJBAR KIA | AGHA ALINEJAD HAMID | SHAHBAZI SHIRIN | Molanori Shamsi Mahdieh | Issue Writer Certificate

Keywords

AutophagyQ1

CancerQ2

Interval exercise trainingQ1

Selinume nanoparticlesQ1

Abstract

The aim of this study was to determine the effects of aerobic interval training and the purported antioxidant treatment, selenium nanoparticle supplementation on the expression of Autophagy in 4T1 breast Cancerbearing mice with cachexia. 3-5 weeks old Balb/c mice were initially assigned to control, interval training, selenium nanoparticles and interval training-selenium nanoparticles (n = 15– 16/group). After 6 weeks of training, half of each group was injected with 4T1 tumor cells, followed by 6 additional weeks of training. Finally, the mice were sacrificed, tissues were removed and were quantified using the Real-time PCR method. The effect of exercise training on the expression of LC3 and the effect of Cancer on mTOR is significant. Combination of interval training and selenium nanoparticles maintained skeletal muscle function in Cancer (P<0. 05). finally, the adaptation of autophagic genes against physiological and pathologic stresses can be considered to be a counterbalance in body effort to modify these conditions and to bring the body to physiological homeostasis.

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APA: Copy

RANJBAR, KIA, AGHA ALINEJAD, HAMID, SHAHBAZI, SHIRIN, & Molanori Shamsi, Mahdieh. (2018). The effect of interval training and selenium nanoparticles on mTOR and LC3 mRNA expression in mice bearing breast cancer. SPORT BIOSCIENCES (HARAKAT), 10(2 ), 177-192. SID. https://sid.ir/paper/380200/en

Vancouver: Copy

RANJBAR KIA, AGHA ALINEJAD HAMID, SHAHBAZI SHIRIN, Molanori Shamsi Mahdieh. The effect of interval training and selenium nanoparticles on mTOR and LC3 mRNA expression in mice bearing breast cancer. SPORT BIOSCIENCES (HARAKAT)[Internet]. 2018;10(2 ):177-192. Available from: https://sid.ir/paper/380200/en

IEEE: Copy

KIA RANJBAR, HAMID AGHA ALINEJAD, SHIRIN SHAHBAZI, and Mahdieh Molanori Shamsi, “The effect of interval training and selenium nanoparticles on mTOR and LC3 mRNA expression in mice bearing breast cancer,” SPORT BIOSCIENCES (HARAKAT), vol. 10, no. 2 , pp. 177–192, 2018, [Online]. Available: https://sid.ir/paper/380200/en

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