The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study

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SAFFAR S.; FATEMI I.; RAHMANI M.R.; HASSANSHAHI J.; Pak Hashemi M.; Kaeidi A.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2020 | Volume:19 | Issue:2 Page(s): 115-124

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Title

The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study

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Keywords

MorphineQ2

EGCGQ1

Working memoryQ1

RatQ2

Abstract

Background and Objectives: Chronic Morphine use leads to structural changes in the brain. Some studies have shown the antioxidant and neuroprotective effects of Epigallocatechin gallate (EGCG) as a main polyphenol of green tea. Therefore, the aim of this study was to investigate the effect of EGCG on Working memory in Morphine-treated Rats. Materials and Methods: In this experimental study, 32 male Wistar Rats were divided into 4 experimental groups (8 Rats in each group): 1-control; 2-Morphine group (the animals received 40 mg/kg Morphine for 4 weeks, once a day, s. c. ); 3 and 4-Morphine + EGCG, the animals received Morphine (40 mg/kg, 4 weeks, once a day, s. c. ) and EGCG (5 and 50 mg/kg, once a day, i. p. ). To evaluate the Working memory, Y-maze spontaneous alternation was used. To measure the level of TNF-α protein expression in brain hippocampus tissue, the western blot test was used. One-way ANOVA with Tukey’ s post hoc test was used for data analysis. Results: Intraperitoneal Morphine injection resulted in Working memory deficits and increased TNF-α protein expression levels compared to the control group (p<0. 001). Moreover, intraperitoneal injection of 50 mg/kg EGCG in Morphine treated Rats significantly improved Working memory (p<0. 01) and decreased TNF-α protein expression level (p<0. 05) compared to solely Morphine treated group. Conclusion: EGCG improved Morphine induced Working memory deficits in Rats.

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APA: Copy

SAFFAR, S., FATEMI, I., RAHMANI, M.R., HASSANSHAHI, J., Pak Hashemi, M., & Kaeidi, A.. (2020). The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 19(2 ), 115-124. SID. https://sid.ir/paper/380303/en

Vancouver: Copy

SAFFAR S., FATEMI I., RAHMANI M.R., HASSANSHAHI J., Pak Hashemi M., Kaeidi A.. The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;19(2 ):115-124. Available from: https://sid.ir/paper/380303/en

IEEE: Copy

S. SAFFAR, I. FATEMI, M.R. RAHMANI, J. HASSANSHAHI, M. Pak Hashemi, and A. Kaeidi, “The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 19, no. 2 , pp. 115–124, 2020, [Online]. Available: https://sid.ir/paper/380303/en

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