Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice

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TAATI R.; FAEZI GHASEMI M.; ASSMAR M.

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Journal: Journal of Guilan University of Medical Sciences Year:2018 | Volume:27 | Issue:105 Page(s): 43-49

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Title

Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice

Author(s)

TAATI R. | FAEZI GHASEMI M. | ASSMAR M. | Issue Writer Certificate

Keywords

ListeriosisQ3

MiceQ3

TetracyclineQ1

TrimethoprimQ3

Abstract

Introduction: Listeriosis is among the diseases occurring to humans, wild and domestic animals. Listeria monocytogenes, the etiologic agent of this disease, is one the most important food-borne pathogens. Given the limited information regarding the effects of various concentrations of different antibiotics on Listeria monocytogenes for in vivo studies, this study is designed. Objective: The aim of this study was to evaluate the inhibitory effects of different concentrations of Tetracycline and Trimethoprim on the prevention of congenital Listeriosis in Balb/C Mice. Materials and Methods: In this experimental-analytical study, the effect of various concentrations of Tetracycline and Trimethoprim on congenital Listeriosis was evaluated in 4 groups of modelBalb/C Mice, (treated with Tetracycline, treated with Trimethoprim, positive control and negative control). Minimum inhibitory concentration for Listeria monocytogenes was determinedin Muller-Hinton broth medium. For in vivo study, different dosages of Tetracycline and Trimethoprim were administered orally. Clinical evidence, sampling and culture methods were used for Listeriosis identification. Results: The obtained results showed that the percentage of live birth was higher in the treated Mice than in the control groups. Using Tetracycline and Trimethoprim prevented abortion in treated Balb/C Mice. For Trimethoprim and Tetracycline were effective for 100% and 74% prevention in abortion, respectively, as observed. Conclusion: Based on the results obtained in this study, it can be concluded thattrimethoprim antibiotic had more inhibitory effects than Tetracycline on the abortion prevention in Balb/C Mice.

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APA: Copy

TAATI, R., FAEZI GHASEMI, M., & ASSMAR, M.. (2018). Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 27(105 ), 43-49. SID. https://sid.ir/paper/380717/en

Vancouver: Copy

TAATI R., FAEZI GHASEMI M., ASSMAR M.. Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(105 ):43-49. Available from: https://sid.ir/paper/380717/en

IEEE: Copy

R. TAATI, M. FAEZI GHASEMI, and M. ASSMAR, “Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 105 , pp. 43–49, 2018, [Online]. Available: https://sid.ir/paper/380717/en

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