Investigation of Expression and Methylation Status of ELF5 Gene Promoter in Patients with Breast Cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Heidarizadi A.; SALIMI M.; MOZDARANI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:28 | Issue:4 Page(s): 66-78

Download Full-Text

Persian Verion

View:

320

Download:

Cites:

Information Journal Paper

Title

Investigation of Expression and Methylation Status of ELF5 Gene Promoter in Patients with Breast Cancer

Author(s)

Heidarizadi A. | SALIMI M. | MOZDARANI H. | Issue Writer Certificate

Keywords

Breast neoplasmsQ1

ELF5Q2

EpigeneticsQ1

Gene expressionQ1

MethylationQ1

Abstract

Introduction: Breast cancer is the most prevalent cancer among Iranian women. ELF5 gene as a transcription factor member of the ETS family could play a key role in breast cancer neoplasms, especially basal-like and endocrine-resistant subtypes. The changes in the gene promoter Methylation pattern are considered proper targets in the therapeutic strategies. This study aimed to investigate the frequency of this epigenetic phenomenon and ELF5 Gene expression as well as their association with pathologic and clinical characteristics of Iranian patients suffering from this cancer. Materials & Methods: In order to investigate the ELF5 promoter Methylation, 134 breast tissues were analyzed using Methylation-specific PCR method. Moreover, 164 tumoral and 10 normal breast tissues retrieved from breast reduction surgery were assessed using Real-Time RT-PCR to analyze the Gene expression. Ethics code: 52d/4922, 6. 10. 2016 Findings: The data revealed that about 70% of the breast cancer tumoral specimens showed ELF5 promoter methylated pattern. Furthermore, the down-regulation of ELF5 Gene expression was significantly associated with higher cancer stages, being triple-negative, and invasion. Discussions & Conclusions: The results revealed that an increase in the ELF5 promoter Methylation frequency in patients, compared to the control tissues, and its association with poor prognosis indicators may propose the ELF5 promoter Methylation as a possible candidate in further studies to confirm the poor prognostic role of this biomarker in breast cancer.

Cites

No record.

References

Cite

APA: Copy

Heidarizadi, A., SALIMI, M., & MOZDARANI, H.. (2020). Investigation of Expression and Methylation Status of ELF5 Gene Promoter in Patients with Breast Cancer. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 28(4 ), 66-78. SID. https://sid.ir/paper/381274/en

Vancouver: Copy

Heidarizadi A., SALIMI M., MOZDARANI H.. Investigation of Expression and Methylation Status of ELF5 Gene Promoter in Patients with Breast Cancer. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(4 ):66-78. Available from: https://sid.ir/paper/381274/en

IEEE: Copy

A. Heidarizadi, M. SALIMI, and H. MOZDARANI, “Investigation of Expression and Methylation Status of ELF5 Gene Promoter in Patients with Breast Cancer,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 4 , pp. 66–78, 2020, [Online]. Available: https://sid.ir/paper/381274/en

Related Journal Papers