EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN TREATMENT ON THE INCIDENCE OF PNEUMONIA IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

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POURPAK Z.; AGHAMOHAMMADI A.; FARHOODI A.; GHARAGOZLOO M.; MOEIN M.; MOVAHEI M.

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Journal: Tehran University Medical Journal Year:2004 | Volume:62 | Issue:5 Page(s): 372-377

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Title

EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN TREATMENT ON THE INCIDENCE OF PNEUMONIA IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

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Keywords

COMMON VARIABLE IMMUNODEFICIENCY (CVID)Q4

PNEUMONIAQ4

INTRAVENOUS IMMUNOGLOBULINQ4

Abstract

Background: common variable immunodeficiency (CVID) is a primary immunodeficiency disorder in which patients are presented by hypogammaglobulinemia and recurrent bacterial infections. CVID is characterized by low levels of serum immunoglobulin. Patients with CVID frequently show respiratory complications and are often presented by frequent and severe episodes of PNEUMONIA before making the diagnosis. The standard treatment INTRAVENOUS IMMUNOGLOBULIN (NIG) has been available for the past 20 years. The aim of this study was to present document on effectiveness of NIG treatment on the incidence of PNEUMONIA in patients with CVID.Materials and Methods: In this study, data were obtained from the clinical files of patients with CVID. The number of episodes of PNEUMONIA and admission to the hospital was documented before and after treatment with NIG. The past medical histories of 26 patients were reviewed (mean current age= 13.4 +/- 5.1 years, age range: 4.5-26.5 years, 16 males and 10 females). Results: Of the 26 patients with CVID, 80.5% had experienced PNEUMONIA, at least once before making the diagnosis and receiving immunoglobulin treatment and 88.5% needed to be admitted to the hospital. After making diagnosis and starting treatment with NIG during mean period of 41.5 +/- 35.4 months, the number of patients experiencing PNEUMONIA significantly decreased to 34.6% (p-value=O.0017) and the need admittance to the hospital reduced to 46% of the patients (p-value=0.0025). During treatment with gamma globulin the incidence of PNEUMONIA requiring treatment or hospitalization fell from 3.3 to 0.6 per patient per year (p-value< 0.0005).Conclusion: Our study demonstrated that treatment with IVIG significantly reduces the incidence of PNEUMONIA.

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APA: Copy

POURPAK, Z., AGHAMOHAMMADI, A., FARHOODI, A., GHARAGOZLOO, M., MOEIN, M., & MOVAHEI, M.. (2004). EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN TREATMENT ON THE INCIDENCE OF PNEUMONIA IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(5), 372-377. SID. https://sid.ir/paper/38132/en

Vancouver: Copy

POURPAK Z., AGHAMOHAMMADI A., FARHOODI A., GHARAGOZLOO M., MOEIN M., MOVAHEI M.. EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN TREATMENT ON THE INCIDENCE OF PNEUMONIA IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2004;62(5):372-377. Available from: https://sid.ir/paper/38132/en

IEEE: Copy

Z. POURPAK, A. AGHAMOHAMMADI, A. FARHOODI, M. GHARAGOZLOO, M. MOEIN, and M. MOVAHEI, “EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN TREATMENT ON THE INCIDENCE OF PNEUMONIA IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 5, pp. 372–377, 2004, [Online]. Available: https://sid.ir/paper/38132/en

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