COMPARISON OF ACUTE TOXICITY IN CONCURRENT AND SEQUENTIAL ADJUVANT
CHEMORADIATION OF BREAST CANCER

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VAKILHA M.; SAMIEI MANESH F.; ELAHI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Tehran University Medical Journal Year:2004 | Volume:62 | Issue:5 Page(s): 405-410

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Information Journal Paper

Title

COMPARISON OF ACUTE TOXICITY IN CONCURRENT AND SEQUENTIAL ADJUVANT CHEMORADIATION OF BREAST CANCER

Author(s)

VAKILHA M. | SAMIEI MANESH F. | ELAHI F. | Issue Writer Certificate

Keywords

CHEMORADIATIONQ4

CHEMOTHERAPYQ4

BREAST CANCER RADICAL MASTECTOMYQ4

ADJUVANTQ4

Abstract

Background: Breast cancer is the most common cancer and the second leading cause of cancer death in women in the world. The sequence and timing of CHEMOTHERAPY and radiotherapy (RT) as ADJUVANT treatment is controversial. In conventional method, CHEMOTHERAPY is used after surgery followed by radiotherapy. Concurrent CHEMORADIATION is reasonable, but the risk of toxicity is high and is the prime concern in this method.Materials and Methods: In this study 70 cases of breast cancer were randomized in two groups. All of tlie patients were treated with ADJUVANT CHEMOTHERAPY (CMF X6). In concurrent group RT began after 3rd or 4th course of CHEMOTHERAPY and in sequential group it began after the 6th course of CHEMOTHERAPY (50 Gray /25 fractions in modified radical mastectomy and 60Gy/30 fractions in breast conservative surgery) 1- Maximum grade of dermatitis was higher in concurrent compared to the sequential group.(p=0.001)2- Maximum grade of neutropenia was higher in concurrent compared to the sequential group. (p=0.024)Conclusion: In conclusion, ADJUVANT concurrent CHEMORADIATION with acceptable toxicity is rational in breast cancer.

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APA: Copy

VAKILHA, M., SAMIEI MANESH, F., & ELAHI, F.. (2004). COMPARISON OF ACUTE TOXICITY IN CONCURRENT AND SEQUENTIAL ADJUVANT CHEMORADIATION OF BREAST CANCER. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(5), 405-410. SID. https://sid.ir/paper/38136/en

Vancouver: Copy

VAKILHA M., SAMIEI MANESH F., ELAHI F.. COMPARISON OF ACUTE TOXICITY IN CONCURRENT AND SEQUENTIAL ADJUVANT CHEMORADIATION OF BREAST CANCER. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2004;62(5):405-410. Available from: https://sid.ir/paper/38136/en

IEEE: Copy

M. VAKILHA, F. SAMIEI MANESH, and F. ELAHI, “COMPARISON OF ACUTE TOXICITY IN CONCURRENT AND SEQUENTIAL ADJUVANT CHEMORADIATION OF BREAST CANCER,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 5, pp. 405–410, 2004, [Online]. Available: https://sid.ir/paper/38136/en

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