ELECTROCHEMICAL STUDY OF ACTIVATED HPB BINDING TO HUMAN SERUM ALBUMIN

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MOHAMMADI ARANI MOSTAFA; MAHDAVI SEYED MOHAMMAD; HEYDARIAN ESFANDIAR; ALIZADEH MOTLAGH N.; AGHAMOHAMMADI M.; RANJBAR B.; MOSTAFAVI MEHRNAZ; MOGHADAMNIA S.H.; MOHAMMADI ARANI REZA; MOHAMMADI ARANI MAJID

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:14 | Issue:4 Page(s): 37-42

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Title

ELECTROCHEMICAL STUDY OF ACTIVATED HPB BINDING TO HUMAN SERUM ALBUMIN

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Keywords

HUMAN SERUM ALBUMINQ3

HEXADESYL PRIDINIUM BROMIDEQ3

TEMPRETUREQ3

Abstract

Introduction: HUMAN SERUM ALBUMIN (HSA) is a single strand protein that plays a major role in the maintenance of plasma oncotic pressure. Surface of this protein is covered with unneutralized negative charges and has an important role in the transfer of some drugs, fatty acids, cations and hormones in the blood was purchased.Materials & Methods: HAS (Hexadesyl pridinium bromide) from Sigma company and the other reagents were recieved from Merck Co. Using Phosphate buffer in pH=7 for all experiments through CD-spectrophotometer (model Jasco) secondary structure changes in the protein were observed. The ligand binding of HSA- HPB interaction was studied by fluke potentiometer. HSA concentration in all experiments was 0.2 mg/ml.Results: HSA CD spectra in the far-UV region were obtained at 37oC and 42oC. The binding isotherms and also scadchard curves for HAS-HPB interaction at 37oC and 42oC were drawn and discussed.Conclusion: Rising temperature from 37oC up to 42oC proved a considerable effect on the structural aspects of HSA. HSA-HPB interaction depends on the temperature so the affinity of HSA for HPB binding reduces as temperature increases to 42oC from 37oC. Therefore, the amounts of negative charges on the surface of HSA at the 42oC are less then those at 37oC and leads to the decrement of blood oncotic pressure. This effect expresses the considerable effect of HSA on the moderation of fever on the body.

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APA: Copy

MOHAMMADI ARANI, MOSTAFA, MAHDAVI, SEYED MOHAMMAD, HEYDARIAN, ESFANDIAR, ALIZADEH MOTLAGH, N., AGHAMOHAMMADI, M., RANJBAR, B., MOSTAFAVI, MEHRNAZ, MOGHADAMNIA, S.H., MOHAMMADI ARANI, REZA, & MOHAMMADI ARANI, MAJID. (2007). ELECTROCHEMICAL STUDY OF ACTIVATED HPB BINDING TO HUMAN SERUM ALBUMIN. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 14(4), 37-42. SID. https://sid.ir/paper/382078/en

Vancouver: Copy

MOHAMMADI ARANI MOSTAFA, MAHDAVI SEYED MOHAMMAD, HEYDARIAN ESFANDIAR, ALIZADEH MOTLAGH N., AGHAMOHAMMADI M., RANJBAR B., MOSTAFAVI MEHRNAZ, MOGHADAMNIA S.H., MOHAMMADI ARANI REZA, MOHAMMADI ARANI MAJID. ELECTROCHEMICAL STUDY OF ACTIVATED HPB BINDING TO HUMAN SERUM ALBUMIN. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;14(4):37-42. Available from: https://sid.ir/paper/382078/en

IEEE: Copy

MOSTAFA MOHAMMADI ARANI, SEYED MOHAMMAD MAHDAVI, ESFANDIAR HEYDARIAN, N. ALIZADEH MOTLAGH, M. AGHAMOHAMMADI, B. RANJBAR, MEHRNAZ MOSTAFAVI, S.H. MOGHADAMNIA, REZA MOHAMMADI ARANI, and MAJID MOHAMMADI ARANI, “ELECTROCHEMICAL STUDY OF ACTIVATED HPB BINDING TO HUMAN SERUM ALBUMIN,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 4, pp. 37–42, 2007, [Online]. Available: https://sid.ir/paper/382078/en

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