CHANGES IN MONOCARBOXYLATE TRANSPORTER 1 AND P53 GENE EXPRESSION BYAEROBIC INTERVAL TRAINING IN THE EXPERIMENTAL COLON CARCINOMA OF MOUSE

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SHIRVANI HOSSEIN; ISANEJAD AMIN; RAHIMI MOSTAFA; BAZGIR BEHZAD; ALIZADEH ALI MOHAMMAD

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Journal: Tehran University Medical Journal Year:2018 | Volume:76 | Issue:5 Page(s): 313-320

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Title

CHANGES IN MONOCARBOXYLATE TRANSPORTER 1 AND P53 GENE EXPRESSION BYAEROBIC INTERVAL TRAINING IN THE EXPERIMENTAL COLON CARCINOMA OF MOUSE

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Keywords

COLONIC NEOPLASMSQ1

INTERVAL TRAININGQ1

MONOCARBOXYLATE TRANSPORT PROTEIN 1Q1

P53 GENEQ1

Abstract

Background: Recent evidence suggests that regular exercise training is effective intreating various aspects of cancer. Therefore, the purpose of this study was to determinethe effect of 8 weeks of aerobic INTERVAL TRAINING on monocarboxylate transporter 1(MCT1) protein and expression of P53 GENE in tumor of colon cancer mice. Methods: The present study was conducted experimentally from May to October 2014at the Exercise Physiology Research Center of Baqiyatallah University of Medical Sciences, Tehran, Iran. Twenty BALB/c mice of age 3 weekly with a mean weight of17. 6± 1. 4 grams were selected and randomly divided into 4 groups: control (N=5), intervaltraining (N=5), colon tumor (N=5) and INTERVAL TRAINING+colon tumor (N=5). Thecancer was induced by subcutaneous injection of a carcinogenic azoxymethane (10mg/kg) once a week for three weeks, and aerobic exercise was performed with rodenttreadmill for 8 weeks and 5 days a week. Forty-eight hours after the last training session, the mice were cleared and colon removed. Measurement of MCT1 protein wasperformed by ELISA and commercial kits (ZellBio, Germany). Real-time polymerasechain reaction (PCR) was used to determine the relative expression of P53 GENE. Datawere analyzed by Kruskal-Wallis test and Mann-Whitney U tests. Results: The results showed a significant increase in MCT1 protein (P< 0. 01) and significantreductions in P53 GENE expression (P< 0. 001) in a colon tumor group comparedto other groups. Also, there was a significant decrease in the level of MCT1 protein(P< 0. 01) and significant increase in P53 GENE expression (P< 0. 001) in the exercisetraining group and exercise training+colon tumor group compared to control group andthe tumor group was observed. Conclusion: The findings of the study showed that aerobic INTERVAL TRAINING reduced theprotein content of MCT1 and increased the expression of P53 GENE (as a tumor inhibitor)in the tumor of colon cancer mice. These factors are portions of the mechanismsinvolved in cancer cell metabolism by which aerobic INTERVAL TRAINING shows part of itstherapeutic effect in colon cancer.

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APA: Copy

SHIRVANI, HOSSEIN, ISANEJAD, AMIN, RAHIMI, MOSTAFA, BAZGIR, BEHZAD, & ALIZADEH, ALI MOHAMMAD. (2018). CHANGES IN MONOCARBOXYLATE TRANSPORTER 1 AND P53 GENE EXPRESSION BYAEROBIC INTERVAL TRAINING IN THE EXPERIMENTAL COLON CARCINOMA OF MOUSE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(5 ), 313-320. SID. https://sid.ir/paper/38214/en

Vancouver: Copy

SHIRVANI HOSSEIN, ISANEJAD AMIN, RAHIMI MOSTAFA, BAZGIR BEHZAD, ALIZADEH ALI MOHAMMAD. CHANGES IN MONOCARBOXYLATE TRANSPORTER 1 AND P53 GENE EXPRESSION BYAEROBIC INTERVAL TRAINING IN THE EXPERIMENTAL COLON CARCINOMA OF MOUSE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(5 ):313-320. Available from: https://sid.ir/paper/38214/en

IEEE: Copy

HOSSEIN SHIRVANI, AMIN ISANEJAD, MOSTAFA RAHIMI, BEHZAD BAZGIR, and ALI MOHAMMAD ALIZADEH, “CHANGES IN MONOCARBOXYLATE TRANSPORTER 1 AND P53 GENE EXPRESSION BYAEROBIC INTERVAL TRAINING IN THE EXPERIMENTAL COLON CARCINOMA OF MOUSE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 5 , pp. 313–320, 2018, [Online]. Available: https://sid.ir/paper/38214/en

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