OUTPATIENT PARENTERAL ANTIMICROBIAL THERAPY IN CHILDREN WITH FEBRILE URINARY TRACT INFECTION: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL

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NASIRI KALMARZI R.; FAHIMI D.; SALAMATI P.; ROSTAMI P.

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Journal: Tehran University Medical Journal Year:2009 | Volume:66 | Issue:10 Page(s): 746-754

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Title

OUTPATIENT PARENTERAL ANTIMICROBIAL THERAPY IN CHILDREN WITH FEBRILE URINARY TRACT INFECTION: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL

Author(s)

NASIRI KALMARZI R. | FAHIMI D. | SALAMATI P. | ROSTAMI P. | Issue Writer Certificate

Keywords

URINARY TRACT INFECTIONQ3

RENALQ3

SCARQ2

DMSAQ3

OUTPATIENTQ3

THERAPYQ3

Abstract

Background: Acute pyelonephritis may lead to permanent RENAL SCARring. The standard recommendation for treatment of febrile children with URINARY TRACT INFECTION (UTI) is hospitalization for intravenous antibiotics. The purpose of this study was to compare the efficacy of OUTPATIENT intravenous ceftriaxone and cefixime versus inpatient of the same regimen for children with febrile UTI.Methods: In a randomized clinical trial, we compared the efficacy of administration two days intravenous ceftriaxone followed by an oral cefixime for eight days (as OUTPATIENT group) versus four days intravenous ceftriaxone followed by an oral cefixime for six days (as inpatient group), in 203 children (99 cases in OUTPATIENT group and 104 cases in inpatient group) 3 months to 15 years of age with febrile UTI, in terms of shortterm clinical outcomes (sterilization of the urine and defeverescence) and long-term morbidity (incidence of reinfection and RENAL SCARring documented by DMSA scintigraphy.Results: Repeat urine cultures were sterile within 48 hours in all children, mean time to defeverescence was 27.58 (SD=±12.62) and 31.44 (SD=±17.06) hours for children in OUTPATIENT and inpatient groups, respectively (P=0.067). Reinfection occurred in 9.1% of OUTPATIENT and 13.4% of inpatient group (P=0.326). RENAL SCARring developed in 11% of children of OUTPATIENT and 7.6% of children of inpatient group (P=0.884). There was no significant difference between the two groups in respect of RENAL SCARring.Conclusions: OUTPATIENT ceftriaxone for two days followed by cefixime to complete a 10 days course can be recommended as a safe and effective treatment for children with febrile UTI.

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APA: Copy

NASIRI KALMARZI, R., FAHIMI, D., SALAMATI, P., & ROSTAMI, P.. (2009). OUTPATIENT PARENTERAL ANTIMICROBIAL THERAPY IN CHILDREN WITH FEBRILE URINARY TRACT INFECTION: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(10), 746-754. SID. https://sid.ir/paper/38246/en

Vancouver: Copy

NASIRI KALMARZI R., FAHIMI D., SALAMATI P., ROSTAMI P.. OUTPATIENT PARENTERAL ANTIMICROBIAL THERAPY IN CHILDREN WITH FEBRILE URINARY TRACT INFECTION: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;66(10):746-754. Available from: https://sid.ir/paper/38246/en

IEEE: Copy

R. NASIRI KALMARZI, D. FAHIMI, P. SALAMATI, and P. ROSTAMI, “OUTPATIENT PARENTERAL ANTIMICROBIAL THERAPY IN CHILDREN WITH FEBRILE URINARY TRACT INFECTION: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 10, pp. 746–754, 2009, [Online]. Available: https://sid.ir/paper/38246/en

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