Kernicterus in neonatal hyperbilirubinemia

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MOSTAFA GHAREHBAGHI MANIZHEH; Ghasempour Masoumeh; HEIDARABADI SEIFOALLAH; ALIZADEH MAHSA

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Journal: Research in Medicine Year:2020 | Volume:44 | Issue:1 Page(s): 296-300

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Title

Kernicterus in neonatal hyperbilirubinemia

Author(s)

MOSTAFA GHAREHBAGHI MANIZHEH | Ghasempour Masoumeh | HEIDARABADI SEIFOALLAH | ALIZADEH MAHSA | Issue Writer Certificate

Keywords

neonateQ3

hyperbilirubinemiaQ1

neonatal jaundiceQ2

exchange transfusionQ3

developmental outcomeQ1

kernicterusQ2

Abstract

Background: hyperbilirubinemia is a common and often benign problem in neonates. Severe neonatal indirect hyperbilirubinemia associated with neurological developmental disabilities, including auditory, cognitive and motor disorders. Motor disorders include dystonia, athetosis that is consistent with lesions of core nuclei. The tone and coordination abnomality are signs of lesion in cerebellum. hyperbilirubinemia and kertnicterus-induced hearing loss include hearing processing imparment and sensorineural hearing loss. The goal of this study was to determine the neurological developmental outcome and kernicterus in children at ages 24-36 months who had severe neonatal hyperbilirubinemia. Materials and Methods: In a longitudinal study, newborns that admitted to hospital with severe neonatal indirect hyperbilirubinemia were followed. In one year, 181 neonates were admited and treated for severe jaundice. At the age 24 to 36 months, 121 cases were followed and evaluated for kernicterus. Results: In this study 121 patients were followed that 52 patients (43%) were girls and 69 (57%) were boys. The age of newborns at admission was 4. 14± 1. 27 days and their birth weight was 3102 ± 559 grams. The mean values of billirubin was 21. 29± 4. 21 mg/dl at the time of hospitalization. Twenty eight patients (19. 83%) had underwent exchange transfusion in addition to intensive phototherapy, of which 8 neonates(6. 61%) had evidence of ABO incompatibiliry. These 8 patients had received intravenous immunglobolin to prevent the need for second exchange transfusion. Among the followed patients, 3 infants (2. 47%) had developmental delay and diagnosed as kernicterus, of which 2 neonates had exchange transfusion due to ABO incompatibility. Conclusion: In this study, less than 3% of infants with severe neonatal hyperbilirubinemia developed kernicterus. It is necessary to inform parents about neonatal jaundice and its complications. Severe jaundice should be taken serious in the first days of life because of risk for kernicterus. Severe neonatal hyperbilirubinemia, if not treated properly and quickly, can cause developmental delay.

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References

Impact of standardized protocol for the management of prolonged neonatal jaundice in a regional setting: an interventional quasi-experimental study

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APA: Copy

MOSTAFA GHAREHBAGHI, MANIZHEH, Ghasempour, Masoumeh, HEIDARABADI, SEIFOALLAH, & ALIZADEH, MAHSA. (2020). Kernicterus in neonatal hyperbilirubinemia. PAJOUHESH DAR PEZESHKI, 44(1 ), 296-300. SID. https://sid.ir/paper/382591/en

Vancouver: Copy

MOSTAFA GHAREHBAGHI MANIZHEH, Ghasempour Masoumeh, HEIDARABADI SEIFOALLAH, ALIZADEH MAHSA. Kernicterus in neonatal hyperbilirubinemia. PAJOUHESH DAR PEZESHKI[Internet]. 2020;44(1 ):296-300. Available from: https://sid.ir/paper/382591/en

IEEE: Copy

MANIZHEH MOSTAFA GHAREHBAGHI, Masoumeh Ghasempour, SEIFOALLAH HEIDARABADI, and MAHSA ALIZADEH, “Kernicterus in neonatal hyperbilirubinemia,” PAJOUHESH DAR PEZESHKI, vol. 44, no. 1 , pp. 296–300, 2020, [Online]. Available: https://sid.ir/paper/382591/en

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