Distribution of Integron Class I in Drug Resistant Pseudomonas aeruginosa Isolated from Clinical Samples

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Sameni Fatemeh; ESMAEILI ALI; DABIRI HOSSEIN; Azargun Robab; GOUDARZI HOSSEIN; MOHAMMADZADEH ALIREZA

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Journal: Research in Medicine Year:2020 | Volume:44 | Issue:1 Page(s): 301-307

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Title

Distribution of Integron Class I in Drug Resistant Pseudomonas aeruginosa Isolated from Clinical Samples

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Keywords

Pseudomonas aeruginosaQ2

;Antibiotic resistanceQ2

;Integron ClassIQ2

Abstract

Background: Purpose: Pseudomonas aeruginosa is an opportunistic pathogen and management and treatment of infections caused by drug resistant strains of P. aeruginosa have become a major challenge (1). The aim of the present study was to investigate the prevalence of resistant isolates of P. aeruginosa class I integron in clinical and environmental samples. Materials and Methods: In current descriptive study on 101 samples, patients with cystic fibrosis admitted to the pediatric ward and patients with burn infections were included. Samples from ulcers and throat were collected and analyzed using microbiological and biochemical methods. Antibiotic susceptibility testing was performed using microbiological and biochemical methods. via disk diffusion method according to CLSI guidelines. DNA was extracted and gene for class I Integrons was amplified. Results: From among 101 strains isolated from patients (37 from cystic fibrosis and 64 from burn patients) 96. 9% were susceptible to colistin and 83. 8% were susceptible to amikacin and Pipracilin. The highest resistance were shown for ceftizoxime (100%) and Ceftriaxone (82. 8%). From the isolated strains, 18 isolates showed complete resistantresistance, 7 showed intermediate resistantresistance, and 76 were pan-susceptible. According to our analysis, 50% of the isolates had MDR resistance. Based on PCR analysis, out of 101 isolates, 60 (%59. 4) had integron class 1 gene. This gene was significantly associated with strains resistant to amikacin, tobromycin, ciprofloxacin, and pipracillin. Conclusions: rThe increase in the resistance of P. aeruginosa to the most available antibiotics, such as colistin, amikacin, and imipenem, is worrying.

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APA: Copy

Sameni, Fatemeh, ESMAEILI, ALI, DABIRI, HOSSEIN, Azargun, Robab, GOUDARZI, HOSSEIN, & MOHAMMADZADEH, ALIREZA. (2020). Distribution of Integron Class I in Drug Resistant Pseudomonas aeruginosa Isolated from Clinical Samples. PAJOUHESH DAR PEZESHKI, 44(1 ), 301-307. SID. https://sid.ir/paper/382592/en

Vancouver: Copy

Sameni Fatemeh, ESMAEILI ALI, DABIRI HOSSEIN, Azargun Robab, GOUDARZI HOSSEIN, MOHAMMADZADEH ALIREZA. Distribution of Integron Class I in Drug Resistant Pseudomonas aeruginosa Isolated from Clinical Samples. PAJOUHESH DAR PEZESHKI[Internet]. 2020;44(1 ):301-307. Available from: https://sid.ir/paper/382592/en

IEEE: Copy

Fatemeh Sameni, ALI ESMAEILI, HOSSEIN DABIRI, Robab Azargun, HOSSEIN GOUDARZI, and ALIREZA MOHAMMADZADEH, “Distribution of Integron Class I in Drug Resistant Pseudomonas aeruginosa Isolated from Clinical Samples,” PAJOUHESH DAR PEZESHKI, vol. 44, no. 1 , pp. 301–307, 2020, [Online]. Available: https://sid.ir/paper/382592/en

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