INDUCING DENDRITIC CELLS MATURATION BY HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND PHA-ACTIVATED T LYMPHOCYTES CONDITIONED MEDIA

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GANJI BAKHSH M.; ASADI M.; NEJATI V.; DELIREZH N.; FAROKHI F.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2012 | Volume:15 | Issue:2 (61) Page(s): 73-83

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Title

INDUCING DENDRITIC CELLS MATURATION BY HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND PHA-ACTIVATED T LYMPHOCYTES CONDITIONED MEDIA

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Keywords

DENDRITIC CELLQ2

ENDOTHELIAL CELLQ2

MATURATIONQ2

T LYMPHOCYTEQ2

Abstract

Background: Since researchers were able to produce DENDRITIC CELLs (DCs) from peripheral blood monocytes, many scientists have been in search of discovering the best way of producing DENDRITIC CELLs and optimizing the DCs MATURATION processes in vitro to treat some diseases. The aim of this study was to investigate the MATURATION of DCs for tumor immunotherapy.Materials and Methods: In this experimental study, DCs were produced in two stages. In the first stage, monocyte cells were converted to immature DCs by GM-CSF and IL-4. In the second stage, immature DCs were made mature in the presence of human umbilical vein ENDOTHELIAL CELLs and PHA -activated T LYMPHOCYTEs conditioned media and MATURATION factors.Results: The produced DCs with appropriate phenotype, phagocytosis ability, and proliferation of T LYMPHOCYTEs stimulation traits could secrete high levels of cytokines.Conclusion: ENDOTHELIAL CELLs and T LYMPHOCYTEs conditioned media can produce Th1 and DC1 in vitro. Therefore, DCs produced through this method are suitable for immunotherapy treatment applications and cancer treatment through treatment cells.

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APA: Copy

GANJI BAKHSH, M., ASADI, M., NEJATI, V., DELIREZH, N., & FAROKHI, F.. (2012). INDUCING DENDRITIC CELLS MATURATION BY HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND PHA-ACTIVATED T LYMPHOCYTES CONDITIONED MEDIA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(2 (61)), 73-83. SID. https://sid.ir/paper/382810/en

Vancouver: Copy

GANJI BAKHSH M., ASADI M., NEJATI V., DELIREZH N., FAROKHI F.. INDUCING DENDRITIC CELLS MATURATION BY HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND PHA-ACTIVATED T LYMPHOCYTES CONDITIONED MEDIA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(2 (61)):73-83. Available from: https://sid.ir/paper/382810/en

IEEE: Copy

M. GANJI BAKHSH, M. ASADI, V. NEJATI, N. DELIREZH, and F. FAROKHI, “INDUCING DENDRITIC CELLS MATURATION BY HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND PHA-ACTIVATED T LYMPHOCYTES CONDITIONED MEDIA,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 2 (61), pp. 73–83, 2012, [Online]. Available: https://sid.ir/paper/382810/en

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