NADPH DIAPHORASE STAINING OF THE CORPUS CAVERNOSUM IN CHOLESTATIC RATS: ROLE OF NITRERGIC AND OPIOID SYSTEMS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADEGHIPOUR H.; GHASEMI MAHDI; DEHGHANI MAHDI; NOUBAKHT MALIHEH; DEHPOUR A.R.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2008 | Volume:66 | Issue:6 Page(s): 367-372

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,067

Download:

Cites:

Information Journal Paper

Title

NADPH DIAPHORASE STAINING OF THE CORPUS CAVERNOSUM IN CHOLESTATIC RATS: ROLE OF NITRERGIC AND OPIOID SYSTEMS

Author(s)

Keywords

CHOLESTASISQ4

ERECTIONQ3

NITRIC OXIDEQ3

OPIOIDSQ2

NALTREXONEQ3

CORPUS CAVERNOSUMQ3

Abstract

Background: Relaxation of the CORPUS CAVERNOSUM plays an important role in penile ERECTION. Previous studies have suggested that NITRIC OXIDE (NO) appears to be the most important relaxant involved in the ERECTION process. The aim of the present study was to evaluate the effect of CHOLESTASIS in nNOS and eNOS activity of CORPUS CAVERNOSUM.Methods: forty-two adult male Sprague-Dawley rats were divided equally into seven groups: control, sham operated, 2-, 7-, and 14-day bile duct-ligated animals, 7-day bile ductligated chronically treated with L-NAME (3 mg/kg/day, i.p.) and 7-day bile duct-ligated animals chronically treated with NALTREXONE (20 mg/kg/day, i.p.). The animals in each group were killed and the cavernosal tissues analyzed histologically by light and transmission electron microscopy, with NOS activity detected on NANC nerves and endothelium using an NADPH-diaphorase staining technique.Results: our results showed that NADPH diaphorase staining in corporal NANC nerves and endothelium of sham-operated and control group had equal intensity. The staining was more intense in 2-day cholestatic rats than in control group, the staining intensity increased in 7-, and 14-day groups too. There were no significant differences between control group and 7-day cholestatic rats that had been treated chronically with L-NAME or NALTREXONE.Conclusions: These results state that in CORPUS CAVERNOSUM of cholestatic rats there is a time-dependent increase in NOS activity of the corporal NANC nerves and endothelium.Inhibition of NITRIC OXIDE and endogenous OPIOIDS by L-NAME or NALTREXONE during CHOLESTASIS may play a key role in preventing the adverse effects of CHOLESTASIS.

Cites

No record.

References

No record.

Cite

APA: Copy

SADEGHIPOUR, H., GHASEMI, MAHDI, DEHGHANI, MAHDI, NOUBAKHT, MALIHEH, & DEHPOUR, A.R.. (2008). NADPH DIAPHORASE STAINING OF THE CORPUS CAVERNOSUM IN CHOLESTATIC RATS: ROLE OF NITRERGIC AND OPIOID SYSTEMS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(6), 367-372. SID. https://sid.ir/paper/38320/en

Vancouver: Copy

SADEGHIPOUR H., GHASEMI MAHDI, DEHGHANI MAHDI, NOUBAKHT MALIHEH, DEHPOUR A.R.. NADPH DIAPHORASE STAINING OF THE CORPUS CAVERNOSUM IN CHOLESTATIC RATS: ROLE OF NITRERGIC AND OPIOID SYSTEMS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(6):367-372. Available from: https://sid.ir/paper/38320/en

IEEE: Copy

H. SADEGHIPOUR, MAHDI GHASEMI, MAHDI DEHGHANI, MALIHEH NOUBAKHT, and A.R. DEHPOUR, “NADPH DIAPHORASE STAINING OF THE CORPUS CAVERNOSUM IN CHOLESTATIC RATS: ROLE OF NITRERGIC AND OPIOID SYSTEMS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 6, pp. 367–372, 2008, [Online]. Available: https://sid.ir/paper/38320/en

Related Journal Papers