DETERMINATION OF ANTIMICROBIAL RESISTANCE PATTERNS AND EXTENDED SPECTRUM β LACTAMASES IN CLINICAL ISOLATES OF E. COLI

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MIRSALEHIAN A.; JABAL AMELI FERESHTEH; MIRAFSHAR S.M.; BAZARJANI F.; GORJIPOUR ALIEH; GOLI H.R.

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Journal: Tehran University Medical Journal Year:2008 | Volume:66 | Issue:6 Page(s): 373-378

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Title

DETERMINATION OF ANTIMICROBIAL RESISTANCE PATTERNS AND EXTENDED SPECTRUM β LACTAMASES IN CLINICAL ISOLATES OF E. COLI

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Keywords

E. COLIQ3

EXTENDED- SPECTRUM BETALACTAMASEQ2

ANTIMICROBIAL RESISTANCEQ2

Abstract

Background: ANTIMICROBIAL RESISTANCE is a growing threat among hospitalized patients.The mortality and morbidity due to antimicrobial-resistant bacteria are severe.Extended-spectrum betalactamase (ESBL) Enterobacteriaceae are especially alarming because they are capable of hydrolyzing third-generation cephalosporins and monobactams. Thus, antimicrobial treatment for infections due to these resistant pathogens will remain under critical scrutiny.Methods: Gram-negative bacterial pathogens were collected from selected centers and were identified by biochemical methods. Of these, 392 E. COLI isolates were tested for antimicrobial susceptibility to 17 antibiotics by the disk agar diffusion (DAD) method.The phenotypes of ESBLs were determined using the disk diffusion synergy test (DDST) as recommended by the interpretative guidelines of the NCCLS.Results: Most of the bacterial resistance in this study was against carbenicillin (78.06%), trimethoprim- sulfamethoxazole (63.21%), and piperacillin (61.98%), with very low resistance to imipenem (0.76%). More than 50% of the isolates were simultaneously resistant to the three antibiotics, carbenicillin, trimethoprimsulfamethoxazole and piperacillin. In total, 99 E. COLI isolates (25.25%) were ESBL positive.Conclusions: Organisms expressing ESBLs in this study were widely distributed, often possessing the multidrug resistance phenotype. Limiting the use of broad-spectrum cephalosporins is recommended to control this high rate of ESBL expression.

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APA: Copy

MIRSALEHIAN, A., JABAL AMELI, FERESHTEH, MIRAFSHAR, S.M., BAZARJANI, F., GORJIPOUR, ALIEH, & GOLI, H.R.. (2008). DETERMINATION OF ANTIMICROBIAL RESISTANCE PATTERNS AND EXTENDED SPECTRUM β LACTAMASES IN CLINICAL ISOLATES OF E. COLI. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(6), 373-378. SID. https://sid.ir/paper/38326/en

Vancouver: Copy

MIRSALEHIAN A., JABAL AMELI FERESHTEH, MIRAFSHAR S.M., BAZARJANI F., GORJIPOUR ALIEH, GOLI H.R.. DETERMINATION OF ANTIMICROBIAL RESISTANCE PATTERNS AND EXTENDED SPECTRUM β LACTAMASES IN CLINICAL ISOLATES OF E. COLI. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(6):373-378. Available from: https://sid.ir/paper/38326/en

IEEE: Copy

A. MIRSALEHIAN, FERESHTEH JABAL AMELI, S.M. MIRAFSHAR, F. BAZARJANI, ALIEH GORJIPOUR, and H.R. GOLI, “DETERMINATION OF ANTIMICROBIAL RESISTANCE PATTERNS AND EXTENDED SPECTRUM β LACTAMASES IN CLINICAL ISOLATES OF E. COLI,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 6, pp. 373–378, 2008, [Online]. Available: https://sid.ir/paper/38326/en

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