THE EFFECT OF BISMUTH SUBCITRATE IN PATIENTS WITH DIARRHEA PREDOMINANT IRRITABLE BOWEL SYNDROME

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KALANI MOHAMAD; FOROUTAN HOSSEIN; RAHIMI AREF; GHOFRANI HADI; AHADPOOR BEHNAMI SHIVA

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Journal: Tehran University Medical Journal Year:2010 | Volume:68 | Issue:6 Page(s): 335-340

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Title

THE EFFECT OF BISMUTH SUBCITRATE IN PATIENTS WITH DIARRHEA PREDOMINANT IRRITABLE BOWEL SYNDROME

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Keywords

IRRITABLE BOWEL SYNDROME (IBS)Q3

BISMUTH SUBCITRATEQ3

ABDOMINAL PAINQ3

DEFECATIONQ2

BLOATINGQ3

Abstract

Background: The irritable bowel syndrome (IBS) is one of the most common chronic medical conditions. Various mechanisms, including altered gut flora and/or small bowel bacterial overgrowth, have been suggested to play a role in the development of gasrelated symptoms aim of study. The clinical evidence of small intestinal bacterial overgrowth as an important etiology of irritable bowel syndrome continues to accumulate. Clinical symptoms of bacterial overgrowth and irritable bowel syndrome are similar; however, a definitive cause-and-effect relationship remains unproven. It is unclear whether motility dysfunction causes bacterial overgrowth or gas products of enteric bacteria affect intestinal motility in irritable bowel syndrome.Methods: In a randomized double-blind placebo-controlled trial consisting of treatment with BISMUTH SUBCITRATE. Primary efficacy variable was subjective symptoms; frequency of ABDOMINAL PAIN, Number of bowel movement & BLOATING/distension.Results: 119 patients were enrolled (59 BISMUTH SUBCITRATE and 60 placebo recipients). At the end of phase 2, all symptom scores dropped significantly both in BISMUTH SUBCITRATE and placebo group (p<0.001). There was not a significant difference in symptom relief with BISMUTH SUBCITRATE versus placebo administration.Conclusions: There was not a significant difference in symptom relief with BISMUTH SUBCITRATE versus placebo in IBS patients. Whether antibiotics can improve quality of life in patients with irritable bowel syndrome warrants further research.Interventions: Participants were randomly assigned to receive 120mg BISMUTH SUBCITRATE four times daily for 14 days (n=59) or placebo (n=60).

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APA: Copy

KALANI, MOHAMAD, FOROUTAN, HOSSEIN, RAHIMI, AREF, GHOFRANI, HADI, & AHADPOOR BEHNAMI, SHIVA. (2010). THE EFFECT OF BISMUTH SUBCITRATE IN PATIENTS WITH DIARRHEA PREDOMINANT IRRITABLE BOWEL SYNDROME. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(6), 335-340. SID. https://sid.ir/paper/38349/en

Vancouver: Copy

KALANI MOHAMAD, FOROUTAN HOSSEIN, RAHIMI AREF, GHOFRANI HADI, AHADPOOR BEHNAMI SHIVA. THE EFFECT OF BISMUTH SUBCITRATE IN PATIENTS WITH DIARRHEA PREDOMINANT IRRITABLE BOWEL SYNDROME. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(6):335-340. Available from: https://sid.ir/paper/38349/en

IEEE: Copy

MOHAMAD KALANI, HOSSEIN FOROUTAN, AREF RAHIMI, HADI GHOFRANI, and SHIVA AHADPOOR BEHNAMI, “THE EFFECT OF BISMUTH SUBCITRATE IN PATIENTS WITH DIARRHEA PREDOMINANT IRRITABLE BOWEL SYNDROME,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 6, pp. 335–340, 2010, [Online]. Available: https://sid.ir/paper/38349/en

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