The Effect of Hypericin on Autism Like Behavior in Maternal Separation Animal Model: An Experimental Study

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Khanjani Jelodar s.; BIGDELI M.R.; HAJIZADEH MOGHADDAM A.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2020 | Volume:19 | Issue:6 Page(s): 569-578

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Title

The Effect of Hypericin on Autism Like Behavior in Maternal Separation Animal Model: An Experimental Study

Author(s)

Khanjani Jelodar s. | BIGDELI M.R. | HAJIZADEH MOGHADDAM A. | Issue Writer Certificate

Keywords

HypericinQ1

Maternal separationQ1

Autistic-like behaviorsQ1

RatQ2

Abstract

Background and Objectives: The stress caused by Ration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Maternal sepaRation in the early days after birth induces autistic behaviors. Hypericin has many biological properties, including antidepressant and anti-inflammation. Therefore, this study aimed at determining Hypericin effect on autism behaviors that induced by Ration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Maternal sepaRation model. Materials and Methods: In this experimental study, Wistar Rats were divided into two control and Ration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Maternal sepaRation groups. The Rats in the Ration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Maternal sepaRation group were subjected to individual sepaRation from their mother for 1 h per day (postnatal day1-9). The Ration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Maternal sepaRation group was divided into 4 subgroups: Autism, fluoxetine, Hypericin (10mg/kg), Hypericin (50mg/kg). Treatment was gavaged in pups on postnatal day 21-34. In the end of day 34, neurobehavioral tests (grooming, social interaction and open field test) were carried out. Statistical analysis and between group comparison were performed using one-way ANOVA followed by Tukey's test. Results: In the pups subjected to individual isolations from their mother, social deficits (p=0. 007), excessive repetitive behavior (p=0. 001), and anxiety (p=0. 001) were increased. Whereas, Hypericin could reduce repetitive behaviors index (p=0. 011), anxiety (p=0. 001) and social interaction deficits (p=0. 031) in the maternal isolation autism Rat model. Conclusion: These findings indicated that Ration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Maternal sepaRation may produce Autistic-like behaviors, and Hypericin through antidepressant effect may be a potential therapeutic agent against autistic-like behavior.

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APA: Copy

Khanjani Jelodar, s., BIGDELI, M.R., & HAJIZADEH MOGHADDAM, A.. (2020). The Effect of Hypericin on Autism Like Behavior in Maternal Separation Animal Model: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 19(6 ), 569-578. SID. https://sid.ir/paper/384105/en

Vancouver: Copy

Khanjani Jelodar s., BIGDELI M.R., HAJIZADEH MOGHADDAM A.. The Effect of Hypericin on Autism Like Behavior in Maternal Separation Animal Model: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;19(6 ):569-578. Available from: https://sid.ir/paper/384105/en

IEEE: Copy

s. Khanjani Jelodar, M.R. BIGDELI, and A. HAJIZADEH MOGHADDAM, “The Effect of Hypericin on Autism Like Behavior in Maternal Separation Animal Model: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 19, no. 6 , pp. 569–578, 2020, [Online]. Available: https://sid.ir/paper/384105/en

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