DIFFUSE LARGE B-CELL LYMPHOMA: A CLINICO- PATHOLOGIC AND PROGNOSTIC STUDY ON 1470 BIOPSY SPECIMENS

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SADIGHI S.; TIRGARY F.; RAAFAT J.; MOHAGHEGHI M.A.; SAFAVI S.; VAZIRI S.

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Journal: Tehran University Medical Journal Year:2009 | Volume:67 | Issue:8 Page(s): 579-584

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Title

DIFFUSE LARGE B-CELL LYMPHOMA: A CLINICO- PATHOLOGIC AND PROGNOSTIC STUDY ON 1470 BIOPSY SPECIMENS

Author(s)

Keywords

NON HODGKIN LYMPHOMAQ3

CLINICOPATHOLOGICQ3

WHOQ3

CLASSIFICATIONQ3

IMMUNOHISTOCHEMISTRYQ3

Abstract

Background: Diffuse large B Cell lymphoma (DLBCL) is the most common subtype of non-Hogkin lymphoma (NHL). We performed a retrospective study of patients with de novo DLBCL treated in the Medical Oncology department of Cancer Institute of Iran, Tehran to assess the CLINICOPATHOLOGIC and IMMUNOHISTOCHEMISTRY correlation and prognosis of the patients.Methods: World Health Organization (WHO) CLASSIFICATION was used to reexamine 1470 biopsy specimens related to the years 1985-2006. After excluding five cases of T Cell large cell lymphoma, 50 Patients diagnosed as DLBCL.Results: Median age of the patients was 45.5 (20-85) years: 60% were male and 30% had primary extra nodal disease. The most common extra nodal sites were bone, gastrointestinal tract and Head and neck areas. The most common stages were stage II (32%), stage III (32%), stage IV (20%) and stage I (16%) retrospectively and 33% had B-symptoms. All of The Patients received chemotherapy (83% CHOP regimen) and 46% treated by radiotherapy after chemotherapy.With a mean follow up time of 32 months, median survival time was 34 (95% CI 24-40) months. Prognostic factors for survival were tumor stage, B-symptoms and early relapse (less than 6 months).Conclusions: Our data showed the importance of IMMUNOHISTOCHEMISTRY method in diagnosis of DLBCL. Although DLBCL is potentially curable with CHOP chemotherapy protocol, addition of monoclonal antibody (Anti CD 20) and finding new prognostic factors to predict early relapse are clearly needed in Iran.

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APA: Copy

SADIGHI, S., TIRGARY, F., RAAFAT, J., MOHAGHEGHI, M.A., SAFAVI, S., & VAZIRI, S.. (2009). DIFFUSE LARGE B-CELL LYMPHOMA: A CLINICO- PATHOLOGIC AND PROGNOSTIC STUDY ON 1470 BIOPSY SPECIMENS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 67(8), 579-584. SID. https://sid.ir/paper/38449/en

Vancouver: Copy

SADIGHI S., TIRGARY F., RAAFAT J., MOHAGHEGHI M.A., SAFAVI S., VAZIRI S.. DIFFUSE LARGE B-CELL LYMPHOMA: A CLINICO- PATHOLOGIC AND PROGNOSTIC STUDY ON 1470 BIOPSY SPECIMENS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;67(8):579-584. Available from: https://sid.ir/paper/38449/en

IEEE: Copy

S. SADIGHI, F. TIRGARY, J. RAAFAT, M.A. MOHAGHEGHI, S. SAFAVI, and S. VAZIRI, “DIFFUSE LARGE B-CELL LYMPHOMA: A CLINICO- PATHOLOGIC AND PROGNOSTIC STUDY ON 1470 BIOPSY SPECIMENS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 67, no. 8, pp. 579–584, 2009, [Online]. Available: https://sid.ir/paper/38449/en

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