Promising role of Bruton s Tyrosine Kinase Inhibitors in Treatment of COVID-19

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baba mahmoodi Abdolreza; REZAEI MITRA; MARJANI MAJID

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Journal: Journal of Medical Council of Iran Year:2020 | Volume:38 | Issue:2 Page(s): 84-91

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Information Journal Paper

Title

Promising role of Bruton s Tyrosine Kinase Inhibitors in Treatment of COVID-19

Author(s)

baba mahmoodi Abdolreza | REZAEI MITRA | MARJANI MAJID | Issue Writer Certificate

Keywords

COVID-19Q1

SARSQ1

COVQ1

2Q1

Bruton Tyrosine Kinase (BTK)Q1

Abstract

Severe acute respiratory syndrome coronavirus-2 has led to a widespread pandemic whose spread is astonishing, its treatment is uncertain, mortality is significant, and associated socioeconomic complications are uncontrollable. Although little is known about the pathogenesis of the disease, severe cases of COVID 19/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 are usually associated with cytokine release syndrome and high serum levels of inflammatory cytokines, which are thought to be the leading cause of death in these patients. Different pathways cause inflammation and the release of cytokines, one of which is the Bruton Tyrosine Kinase (BTK) pathway, which is important for the production of several anti-inflammatory cytokines. Theoretically, inhibition of BTK signaling could reduce cytokine levels and subsequent anti-inflammatory effects. The purpose of this review article is to investigate the role of BTK in the pathogenesis of COVID 19/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 disease and the possible effects of its inhibitory drugs in the treatment of this disease...

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APA: Copy

baba mahmoodi, Abdolreza, REZAEI, MITRA, & MARJANI, MAJID. (2020). Promising role of Bruton s Tyrosine Kinase Inhibitors in Treatment of COVID-19. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 38(2 ), 84-91. SID. https://sid.ir/paper/384693/en

Vancouver: Copy

baba mahmoodi Abdolreza, REZAEI MITRA, MARJANI MAJID. Promising role of Bruton s Tyrosine Kinase Inhibitors in Treatment of COVID-19. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2020;38(2 ):84-91. Available from: https://sid.ir/paper/384693/en

IEEE: Copy

Abdolreza baba mahmoodi, MITRA REZAEI, and MAJID MARJANI, “Promising role of Bruton s Tyrosine Kinase Inhibitors in Treatment of COVID-19,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 38, no. 2 , pp. 84–91, 2020, [Online]. Available: https://sid.ir/paper/384693/en

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