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Information Journal Paper

Title

Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats

Pages

  473-480

Abstract

 Background: Due to the antioxidant effects of saffron in improving diabetes, this study was conducted in order to investigate the effects of Crocin on pituitary-adrenal axis and Thyroid hormones in diabetic Rats. Materials and Methods: In this experimental study, which was performed at Payame Noor University, 28 male Rats were divided into 4 groups: control, untreatment diabetic, 2 Crocin (50, 100 mg/ml, 25 days intraperitoneal injection)-treated diabetic groups. The diabetic groups obtained with intraperitoneal injection of streptozotocin. Blood sampled from the heart of the Rats 25 days after the start of the experimental. Then, pituitary-adrenal axis hormones (cortisol, aldosterone, adrenocorticotropin, and Thyroid hormones (TSH, T3, and T4)) were evaluated. The results were analyzed by Kruskal Wallis and LSD tests. Results: Crocin at concentRations of 50 and 100 mg/ml has led to a significant increase in cortisol, aldosterone, and adrenocorticotropin compared to the diabetic Rats. Diabetes causes a significant decrease in the levels of Thyroid hormones (TSH, T3, and T4). Prescribing Crocin at concentRations of 50 and 100 mg/ml has significantly increased the level of Thyroid hormones compared to the untreatment diabetic group (P<0. 05). Comparing the two concentRations of Crocin, the group treated with the concentRation of 100 mg/ml has showed a significant increase in the studied indices compared to the group treated with 50 mg/ml of Crocin. Also, crosin significantly reduced the level of glucose in diabetic Rats. Conclusion: Crocin can increase the level of pituitary-adrenal and Thyroid hormones in diabetic male Rats.

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    APA: Copy

    RAHBARIAN, R., & ATAEI, GH.. (2020). Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats. FEYZ, 24(5 ), 473-480. SID. https://sid.ir/paper/385145/en

    Vancouver: Copy

    RAHBARIAN R., ATAEI GH.. Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats. FEYZ[Internet]. 2020;24(5 ):473-480. Available from: https://sid.ir/paper/385145/en

    IEEE: Copy

    R. RAHBARIAN, and GH. ATAEI, “Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats,” FEYZ, vol. 24, no. 5 , pp. 473–480, 2020, [Online]. Available: https://sid.ir/paper/385145/en

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