Effect of Crocin on Bax, Bcl2, and Oxidative Stress Indices in Testicular Tissue of Streptozotocin Diabetic Rats

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Ataei Ghazal; Rahbarian Raheleh; RAJABIAN NOGHONDAR MAJID

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Journal: Internal Medicine Today Year:2019 | Volume:25 | Issue:4 Page(s): 340-351

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Information Journal Paper

Title

Effect of Crocin on Bax, Bcl2, and Oxidative Stress Indices in Testicular Tissue of Streptozotocin Diabetic Rats

Author(s)

Ataei Ghazal | Rahbarian Raheleh | RAJABIAN NOGHONDAR MAJID | Issue Writer Certificate

Keywords

CrocinQ1

Bax proteinQ2

Bcl2 proteinsQ1

TesticleQ2

Diabetes mellitusQ2

RatQ2

Abstract

Aims Type 1 diabetes is a high-prevalent endocrine disease and causes oxidative stress in the testis tissue. In the treatment of diabetes, the tendency toward herbal medicines use is increasing. This study aimed to investigate the Crocin effect on the Bax, Bcl2 (B-cell lymphoma 2), and anti-oxidant levels of streptozotocin-induced diabetic Rats. Methods & Materials This experimental study was performed at Payam Noor University. In total, 24 Rats were divided into 4 groups, as follows: control, untreated diabetic, and 2 Crocin-treated (50, 100 mg/mL, 25 days intraperitoneal injection) diabetic groups. The diabetic groups were diabetic Rats receiving the Intraperitoneal (IP) injection of Streptozotocin (STZ). On day 25, the Testicles were dissected to evaluate antioxidant enzymes, Bax and Bcl2. The obtained results were analyzed in SPSS using One-Way Analysis of Variance (ANOVA) and Least Significant Difference (LSD) test. Findings The pro-apoptotic Bax and malondialdehyde levels in the treated group with a concentRation of 100 mg/mL of Crocin was significantly reduced, compared to the treated group with a concentRation of 50 mg/mL of Crocin and the control group. However, the level of pro-apoptotic Bcl-2 and glutathione peroxidase, superoxide dismutase, and catalase enzymes in the treated group with a concentRation of 100 mg/ mL of Crocin significantly increased, compared to the treated group with a concentRation of 50 mg/mL of Crocin, and the control group (P<0. 05). Such finding indicates the effect of Crocin concentRation. Additionally, crosin significantly reduced the glucose level in diabetic Rats. Conclusion Crocin improved the antioxidant indicators and diabetes-induced damages in the testis tissue of diabetic Rats.

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APA: Copy

Ataei, Ghazal, Rahbarian, Raheleh, & RAJABIAN NOGHONDAR, MAJID. (2019). Effect of Crocin on Bax, Bcl2, and Oxidative Stress Indices in Testicular Tissue of Streptozotocin Diabetic Rats. OFOGH-E-DANESH, 25(4 ), 340-351. SID. https://sid.ir/paper/377163/en

Vancouver: Copy

Ataei Ghazal, Rahbarian Raheleh, RAJABIAN NOGHONDAR MAJID. Effect of Crocin on Bax, Bcl2, and Oxidative Stress Indices in Testicular Tissue of Streptozotocin Diabetic Rats. OFOGH-E-DANESH[Internet]. 2019;25(4 ):340-351. Available from: https://sid.ir/paper/377163/en

IEEE: Copy

Ghazal Ataei, Raheleh Rahbarian, and MAJID RAJABIAN NOGHONDAR, “Effect of Crocin on Bax, Bcl2, and Oxidative Stress Indices in Testicular Tissue of Streptozotocin Diabetic Rats,” OFOGH-E-DANESH, vol. 25, no. 4 , pp. 340–351, 2019, [Online]. Available: https://sid.ir/paper/377163/en

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