CHANGES IN ACTN3 GENE EXPRESSION AND FIBER TYPE COMPOSITION IN FLEXOR HALLUCIS LONGUS MUSCLE AFTER EIGHT WEEKS PROGRESSIVE RESISTANCE TRAINING IN SPRAGUE-DAWLEY RATS

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GAEINI ABBAS ALI; KHALEDI NEDA; FAYAZMILANI RANA; RAVASI ALIASGHAR; SEDGHROOHI GOLNOOSH; ARABKARI VAHID

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2013 | Volume:71 | Issue:1 Page(s): 37-45

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Title

CHANGES IN ACTN3 GENE EXPRESSION AND FIBER TYPE COMPOSITION IN FLEXOR HALLUCIS LONGUS MUSCLE AFTER EIGHT WEEKS PROGRESSIVE RESISTANCE TRAINING IN SPRAGUE-DAWLEY RATS

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Keywords

ALPHA-ACTININSQ2

FLEXOR HALLUCIS LONGUSQ2

RESISTANCE TRAININGQ2

VERTICAL LADDERQ2

Z-LINQ2

Abstract

Background: ALPHA-ACTININS are located in the skeletal muscle Z-LINe and form actin– actin cross-links. It belongs to a highly conserved family of actin-binding proteins- the spectrin superfamily, which also contains the spectrins and dystrophin. Mammalian skeletal muscle has two isoforms: ALPHA-ACTININS-2 and ALPHA-ACTININS-3. However, the response of ALPHA-ACTININS to exercise training is little understood. This study examined the effects of 8 weeks of RESISTANCE TRAINING on muscle mass, ACTN3 (ALPHA-ACTININS-3) gene expression levels and fiber type composition in the FLEXOR HALLUCIS LONGUS (FHL) muscle.Methods: Forty five female Sprague-Dawley rats (Initial body mass: 169.25±9gr age: 3 month) were obtained and assigned to a control (C; n=18) or exercise training (T; n=22) and pilot (P; n=5) groups. The RESISTANCE TRAINING consisted of climbing a ladder carrying a load suspended from the tail and the weight increased progressively. Real-time PCR and Immunohistochemistry techniques were used to measure gene expression levels and myosin heavy chain (MyHC) composition, respectively.Results: Following 8 weeks of training, we observed significant increase in absolute muscle mass in FHL (P=0.01). Results showed that no significant difference was found in ACTN3 gene expression levels between training and control groups (P=0.852 respectively).Also, Pearson coefficient didn' t indicated any significant relationships in gene expression and Fiber type IIX in response to RESISTANCE TRAINING in FHL (r=0.12).Conclusion: However, RESISTANCE TRAINING effects on sarcomeric proteins development, these results showed no effect of RESISTANCE TRAINING on ALPHA-ACTININS-3 levels. Although ALPHA-ACTININS-3 has an important function to produce and progress of force in sarcomere, but didn' t changed significantly in response to RESISTANCE TRAINING.

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APA: Copy

GAEINI, ABBAS ALI, KHALEDI, NEDA, FAYAZMILANI, RANA, RAVASI, ALIASGHAR, SEDGHROOHI, GOLNOOSH, & ARABKARI, VAHID. (2013). CHANGES IN ACTN3 GENE EXPRESSION AND FIBER TYPE COMPOSITION IN FLEXOR HALLUCIS LONGUS MUSCLE AFTER EIGHT WEEKS PROGRESSIVE RESISTANCE TRAINING IN SPRAGUE-DAWLEY RATS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 71(1), 37-45. SID. https://sid.ir/paper/38558/en

Vancouver: Copy

GAEINI ABBAS ALI, KHALEDI NEDA, FAYAZMILANI RANA, RAVASI ALIASGHAR, SEDGHROOHI GOLNOOSH, ARABKARI VAHID. CHANGES IN ACTN3 GENE EXPRESSION AND FIBER TYPE COMPOSITION IN FLEXOR HALLUCIS LONGUS MUSCLE AFTER EIGHT WEEKS PROGRESSIVE RESISTANCE TRAINING IN SPRAGUE-DAWLEY RATS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2013;71(1):37-45. Available from: https://sid.ir/paper/38558/en

IEEE: Copy

ABBAS ALI GAEINI, NEDA KHALEDI, RANA FAYAZMILANI, ALIASGHAR RAVASI, GOLNOOSH SEDGHROOHI, and VAHID ARABKARI, “CHANGES IN ACTN3 GENE EXPRESSION AND FIBER TYPE COMPOSITION IN FLEXOR HALLUCIS LONGUS MUSCLE AFTER EIGHT WEEKS PROGRESSIVE RESISTANCE TRAINING IN SPRAGUE-DAWLEY RATS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 71, no. 1, pp. 37–45, 2013, [Online]. Available: https://sid.ir/paper/38558/en

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