CLINICOPATHOLOGICAL STUDY AND RESULTS OF TREATMENT IN 502 CHILDREN WITH PRIMARY NEPHROTIC SYNDROME (1981-2000)

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MADANI ABAS; ATAEI N.; FALAK ALAFLAKI B.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2003 | Volume:61 | Issue:1 Page(s): 71-79

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Title

CLINICOPATHOLOGICAL STUDY AND RESULTS OF TREATMENT IN 502 CHILDREN WITH PRIMARY NEPHROTIC SYNDROME (1981-2000)

Author(s)

MADANI ABAS | ATAEI N. | FALAK ALAFLAKI B. | Issue Writer Certificate

Keywords

PRIMARY NEPHROTIC SYNDROMEQ4

CLINICOPATHOLOGICAL STUDY - TREATMENT - OUTCOMEQ4

Abstract

Introduction: PRIMARY NEPHROTIC SYNDROME (PNS) accounts for approximately 90% of nephrosis in childhood. There are well defined therapeutic protocols for childhood nephrosic syndrome to minimizing side effects of corticosteroid and repeated relapses. The aim of this study was to assess the clinicopathological aspects and results of treatment in children with PNS.Methods and Materials: We evaluated 502 patients with PNS from 1981-2000. Among these children 5 (1%) achieved spontaneous remission, and 313 children were initial responder. One hundred eighty four patients received at least 1 kidney biopsy (78 prior and 106 after initiation of treatment).Results: Of these patients histology showed minimal change nephrosic syndrome (MCNS) in 67 (36.4%), focal segmental glomerular sclerosis (FSGS) in 41 (22.3%), diffuse mesangial proliferation (DMP) in 28 (15.2%), membranoproliferative glomerulonephritis (MPGN) in 21 (11.4%), focal proliferative glomerulonephritis (FPGN) in 12 (6.5%), congenital nephrosic syndrome (CNS) in 8 (4.3%) and membranous nephropathy (MN) in 7 (3.8%). Of 103 children with frequently relapsing steroid sensitive and steroid dependent idiopathic nephrosis, levamisol induced prolong remission in 33 (31.7%) patients. Cyclophosphamid and cyclosporine induced remission in 49 (50%) of 98 and 28 (41.3%) of 68 patients respectively.Conclusion: Our observation suggests that patients with steroid-dependent nephrosic syndrome or MCNS had better response to cyclophosphamide or cyclosporine than patients with steroid-resistant nephrosic syndrome or FSGS (P<0.05). Additionally , our experience indicate that levamisole treatment is of considerable clinical benefit in patients with frequent relapsers and steroid dependent nephrosic syndrome.

Cites

IDIOPATHIC NEPHROTIC SYNDROME: LINICOPATHOLOGICAL STUDY IN CHILDREN'S TEACHING HOSPITAL OF TABRIZ

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APA: Copy

MADANI, ABAS, ATAEI, N., & FALAK ALAFLAKI, B.. (2003). CLINICOPATHOLOGICAL STUDY AND RESULTS OF TREATMENT IN 502 CHILDREN WITH PRIMARY NEPHROTIC SYNDROME (1981-2000). TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 61(1), 71-79. SID. https://sid.ir/paper/38615/en

Vancouver: Copy

MADANI ABAS, ATAEI N., FALAK ALAFLAKI B.. CLINICOPATHOLOGICAL STUDY AND RESULTS OF TREATMENT IN 502 CHILDREN WITH PRIMARY NEPHROTIC SYNDROME (1981-2000). TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2003;61(1):71-79. Available from: https://sid.ir/paper/38615/en

IEEE: Copy

ABAS MADANI, N. ATAEI, and B. FALAK ALAFLAKI, “CLINICOPATHOLOGICAL STUDY AND RESULTS OF TREATMENT IN 502 CHILDREN WITH PRIMARY NEPHROTIC SYNDROME (1981-2000),” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 61, no. 1, pp. 71–79, 2003, [Online]. Available: https://sid.ir/paper/38615/en

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