THE EFFECT OF SPIRONOLACTONE ON CONCENTRATION OF LH, FSH, TESTOSTERONE DI-HYDROTESTOSTERONE AND SPERMATOGENESIS IN RATS

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MOKHTARI M.; SHARIATI M.; TADAYON N.

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Paper Information

Journal: Journal of Ardabil University of Medical Sciences Year:2007 | Volume:7 | Issue:1 (23) Page(s): 62-68

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Title

THE EFFECT OF SPIRONOLACTONE ON CONCENTRATION OF LH, FSH, TESTOSTERONE DI-HYDROTESTOSTERONE AND SPERMATOGENESIS IN RATS

Author(s)

MOKHTARI M. | SHARIATI M. | TADAYON N. | Issue Writer Certificate

Keywords

SPIRONOLACTONEQ3

LHQ2

FSHQ3

TESTOSTERONEQ2

DI-HYDROTESTOSTERONEQ3

SPERMA OGENESISQ2

RATQ2

Abstract

Background & Objectives: SPIRONOLACTONE is a diuretic and antiandrogenic drug and is used in the trea ment of hypertention secondary hyprealdosteronism; congestive heart failure' cirrhosis of the liver, nephrotic syndrome 'androgenic alopecia' gynecomastia and hirsutism. In this research, the effects of SPIRONOLACTONE on the serum LH, FSH, TESTOSTERONE, dihydrotestosterone, and changes in body weight and testicular tissue in adult male RATs, were studied.Methods: For this purpose 190±10 g male wistar RATs (n=40) were randomly divided into the following groups: control, sham operated (received water) and 25, 50, 100 mg/kg oral SPIRONOLACTONE treated groups. After 14 days body weight and testis weight under laboratory methods, were measured and blood samples were taken from heart and used for the measuring of LH/FSH/testosterone and dihydrotestosterone and then the RATes' testes, in order to evaluate the histological changes, were removed and weighed and after obtaining tissue section and staining through HE, they were studied.Results: Serum LH level showed a significant increase and testos erone and dihydrotestosterone levels showed significant decrease in 100mg/kg SPIRONOLACTONE treated group (p£0.05) and there was no significant difference among serum FSH level, body weight and testicular weight as compared to control group.Conclusion: It can be concluded that oral administration of SPIRONOLACTONE maxima dose for 14 days could increase serum LHlevel and decrease TESTOSTERONE and dihydrorestosterone levels.

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APA: Copy

MOKHTARI, M., SHARIATI, M., & TADAYON, N.. (2007). THE EFFECT OF SPIRONOLACTONE ON CONCENTRATION OF LH, FSH, TESTOSTERONE DI-HYDROTESTOSTERONE AND SPERMATOGENESIS IN RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 7(1 (23)), 62-68. SID. https://sid.ir/paper/386207/en

Vancouver: Copy

MOKHTARI M., SHARIATI M., TADAYON N.. THE EFFECT OF SPIRONOLACTONE ON CONCENTRATION OF LH, FSH, TESTOSTERONE DI-HYDROTESTOSTERONE AND SPERMATOGENESIS IN RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2007;7(1 (23)):62-68. Available from: https://sid.ir/paper/386207/en

IEEE: Copy

M. MOKHTARI, M. SHARIATI, and N. TADAYON, “THE EFFECT OF SPIRONOLACTONE ON CONCENTRATION OF LH, FSH, TESTOSTERONE DI-HYDROTESTOSTERONE AND SPERMATOGENESIS IN RATS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 7, no. 1 (23), pp. 62–68, 2007, [Online]. Available: https://sid.ir/paper/386207/en

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