NPM1 AND FLT3- (ITD) GENE MUTATIONS AND LABORATORY FINDINGS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN NORTHWEST OF IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SANAAT Z.; SHAMS K.; NEJATI B.; MOVASGHPOUR A.K.; Imani v.; MOGHADASZADEH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2015 | Volume:16 | Issue:4 (52) Page(s): 80-86

Download Full-Text

Persian Verion

View:

712

Download:

Cites:

Information Journal Paper

Title

NPM1 AND FLT3- (ITD) GENE MUTATIONS AND LABORATORY FINDINGS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN NORTHWEST OF IRAN

Author(s)

Keywords

ACUTE MYELOID LEUKEMIAQ2

NPM1 GENEQ2

FLT3-ITD GENEQ2

LEUKOCYTOSISQ2

Abstract

Background and Objective: The ACUTE MYELOID LEUKEMIA (AML) is a malignant disease with an accumulation of the abnormal and undifferentiated blastic myeloid cell in the bone marrow, leading to abnormal hematopoiesis. This study was done to determine the NPM1 and FLT3- (ITD) mutations and laboratory findings in patients with ACUTE MYELOID LEUKEMIA.Methods: This descriptive-analytic study was carried out on 40 (24 males, 16 females) patients with newly ACUTE MYELOID LEUKEMIA in Northwest of Iran. The mutation of NPM1 and FLT3-ITD were evaluated using PCR method in 25 patients. In all patients, the flowcytometry findings in the bone marrow, leucocytosis and the LDH levels were evaluated prior to the chemotherapy.Results: The mutation of FLT3-ITD and NPM1 GENEs was detected in 15 (60%) and 9 (36%) of patients, respectively. FLT3-NPM1+mutation was seen in 4 (16%) patients. LEUKOCYTOSIS, LDH level and AML in different classes did no show any significant difference between FLT3-NPM1+and other gene mutations.Conclusion: The mutation of FLT3-ITD GENE was nearly twice than NPM1 in ACUTE MYELOID LEUKEMIA.

Cites

No record.

References

No record.

Cite

APA: Copy

SANAAT, Z., SHAMS, K., NEJATI, B., MOVASGHPOUR, A.K., Imani, v., & MOGHADASZADEH, M.. (2015). NPM1 AND FLT3- (ITD) GENE MUTATIONS AND LABORATORY FINDINGS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN NORTHWEST OF IRAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(4 (52)), 80-86. SID. https://sid.ir/paper/78948/en

Vancouver: Copy

SANAAT Z., SHAMS K., NEJATI B., MOVASGHPOUR A.K., Imani v., MOGHADASZADEH M.. NPM1 AND FLT3- (ITD) GENE MUTATIONS AND LABORATORY FINDINGS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN NORTHWEST OF IRAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;16(4 (52)):80-86. Available from: https://sid.ir/paper/78948/en

IEEE: Copy

Z. SANAAT, K. SHAMS, B. NEJATI, A.K. MOVASGHPOUR, v. Imani, and M. MOGHADASZADEH, “NPM1 AND FLT3- (ITD) GENE MUTATIONS AND LABORATORY FINDINGS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN NORTHWEST OF IRAN,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 4 (52), pp. 80–86, 2015, [Online]. Available: https://sid.ir/paper/78948/en

Related Journal Papers