Study of Structural and Immunological Properties of Glycoprotein S of the East Respiratory Syndrome Coronavirus (MERS-CoV)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hasanshahi Z.; DEHGHANI B.; HASHEMPOUR T.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2020 | Volume:23 | Issue:1 Page(s): 33-39

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

359

Download:

Cites:

Information Journal Paper

Title

Study of Structural and Immunological Properties of Glycoprotein S of the East Respiratory Syndrome Coronavirus (MERS-CoV)

Author(s)

Hasanshahi Z. | DEHGHANI B. | HASHEMPOUR T. | Issue Writer Certificate

Keywords

Glycoprotein SQ1

MERSQ1

RBDQ1

Abstract

Aims No definitive treatment or effective vaccine has been suggested against the East Respiratory Syndrome Coronavirus (MERS-CoV) virus which indicates the growing importance of the study of this virus. Amongst all MERS proteins, Glycoprotein S has always been the main candidate for vaccine research against this virus, due to its function and structure. The aim of the present study was to investigate the structural, functional, and immunological properties of S protein using bioinformatics software that paves the way for designing an effective vaccine against this virus. Materials & Methods 35 Glycoprotein S sequences of MERS were obtained from Genbank and amino acid changes were investigated. In addition, sequences were analyzed by various software for post-translational changes. Five types of software were used to evaluate the immunologic and allergenic properties. Finally, different structural aspects of this protein were predicted by SOPMA software. Findings The highest prevalence substitutions were found in amino acids of 95, 123, and 696 and the results indicate that there are four B-cell epitopes in Glycoprotein S, and this protein has been affected by post-translational changes, including glycosylation and phosphorylation. This protein has no allergenic properties and the majority of its structure contains Alpha helix. Conclusion Glycoprotein S, especially in the RBD region of S1, has a high potential to induce the host immune system and the other features mentioned protein make it appropriate for the production of recombinant protein, including stability in host cells. Therefore, the use of Glycoprotein S, especially S1, is recommended as a suitable candidate for vaccine design.

Cites

No record.

References

No record.

Cite

APA: Copy

Hasanshahi, Z., DEHGHANI, B., & HASHEMPOUR, T.. (2020). Study of Structural and Immunological Properties of Glycoprotein S of the East Respiratory Syndrome Coronavirus (MERS-CoV). PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(1 ), 33-39. SID. https://sid.ir/paper/386487/en

Vancouver: Copy

Hasanshahi Z., DEHGHANI B., HASHEMPOUR T.. Study of Structural and Immunological Properties of Glycoprotein S of the East Respiratory Syndrome Coronavirus (MERS-CoV). PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2020;23(1 ):33-39. Available from: https://sid.ir/paper/386487/en

IEEE: Copy

Z. Hasanshahi, B. DEHGHANI, and T. HASHEMPOUR, “Study of Structural and Immunological Properties of Glycoprotein S of the East Respiratory Syndrome Coronavirus (MERS-CoV),” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 1 , pp. 33–39, 2020, [Online]. Available: https://sid.ir/paper/386487/en

Related Journal Papers