CYTOTOXIC EFFECTS OF LAGENARIA SICERARIA STANDL. EXTRACT ON CANCER CELL LINE

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SHOKRZADEH MOHAMMAD; PARVARESH ATEFEH; SHAHANI SOMAYEH; HABIBI EMRAN; ZALZAR ZAVOSH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2013 | Volume:22 | Issue:97 Page(s): 225-230

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Title

CYTOTOXIC EFFECTS OF LAGENARIA SICERARIA STANDL. EXTRACT ON CANCER CELL LINE

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Keywords

LAGENARIA SICERARIAQ2

TUMOR CELL LINESQ2

GROWTH INHIBITORSQ2

MTT ASSAYQ2

Abstract

Background and purpose: In most cases, drugs used for chemotherapy are ineffective and have unpleasant side-effects. This has made scientists to find more effective drugs with less toxicity. LAGENARIA SICERARIA is an important medicinal plant in the world and anti-tumoral activity of Lagenaria species has been reported in some studies. This study was designed to evaluate the anti-tumoral effect of methanolic extract isolated from LAGENARIA SICERARIA on lung cancer cell line.Materials and methods: Hydroalcoholic extract of LAGENARIA SICERARIA was prepared by percolation method. Cultivated cancer cell line of lung (A549) was incubated with different concentrations (0.1, 1, 10, 100, 250, 1000, 500, and 5000 mg/ml) of the extract for 72 hours and cell growth inhibition was determined using MTT ASSAY. Cisplatin was considered as positive control. The resulting data was analyzed using ANOVA and t-test.Results: Results of MTT ASSAY showed strong and dose-dependent inhibition of cancer cell growth by the extract of LAGENARIA SICERARIA. This extract caused a significant decrease in proliferation of lung cancer cell line (IC50=93.094±6.5 mg/ml).Conclusion: The results of this study suggest anti-tumoral activity of LAGENARIA SICERARIA, however, isolation of efficient compounds of this extract and evaluation of their effects on tumor-bearing animal models are suggested.

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APA: Copy

SHOKRZADEH, MOHAMMAD, PARVARESH, ATEFEH, SHAHANI, SOMAYEH, HABIBI, EMRAN, & ZALZAR, ZAVOSH. (2013). CYTOTOXIC EFFECTS OF LAGENARIA SICERARIA STANDL. EXTRACT ON CANCER CELL LINE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(97), 225-230. SID. https://sid.ir/paper/387414/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, PARVARESH ATEFEH, SHAHANI SOMAYEH, HABIBI EMRAN, ZALZAR ZAVOSH. CYTOTOXIC EFFECTS OF LAGENARIA SICERARIA STANDL. EXTRACT ON CANCER CELL LINE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;22(97):225-230. Available from: https://sid.ir/paper/387414/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, ATEFEH PARVARESH, SOMAYEH SHAHANI, EMRAN HABIBI, and ZAVOSH ZALZAR, “CYTOTOXIC EFFECTS OF LAGENARIA SICERARIA STANDL. EXTRACT ON CANCER CELL LINE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 97, pp. 225–230, 2013, [Online]. Available: https://sid.ir/paper/387414/en

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