ASSOCIATION BETWEEN G-2548A LEPTIN GENE POLYMORPHISM AND BREAST CANCER RISK

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ROSTAMI SARA; KOHAN LEILA; MOHAMMADIANPANAH MOHAMMAD; FEREIDUNI FERESHTEH

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2014 | Volume:72 | Issue:6 Page(s): 360-366

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Title

ASSOCIATION BETWEEN G-2548A LEPTIN GENE POLYMORPHISM AND BREAST CANCER RISK

Author(s)

ROSTAMI SARA | KOHAN LEILA | MOHAMMADIANPANAH MOHAMMAD | FEREIDUNI FERESHTEH | Issue Writer Certificate

Keywords

BREAST NEOPLASMSQ2

GENOTYPEQ3

LEPTINQ2

POLYMORPHISMQ2

Abstract

Background: LEPTIN is an adipokine made by fat cells and plays a key role in proliferation, cell survival, migration and immune response. Several studies have suggested that individuals with high serum LEPTIN concentrations would increase the risk of breast cancer. G -2548A POLYMORPHISM in the LEPTIN gene is located in the promoter region and is associated with the change of LEPTIN serum level. In this study, the association between G -2548A POLYMORPHISM in LEPTIN gene and breast cancer susceptibility was investigated.Methods: This case-control study was done on 374 Iranian women. This study was performed from March 2013 to February 2013. Blood samples from 203 women with breast cancer and 171 age (±5) - matched healthy women were collected. Breast cancer patients were selected from Namazi Hospital in Shiraz city. Genomic DNA was extracted from blood samples. The G -2548A POLYMORPHISM of LEPTIN gene was determined using polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) method. Data analysis was performed by SPSS version 18. Logistic regression analysis was used for association of breast cancer susceptibility and G -2548A POLYMORPHISM of LEPTIN gene.Results: The A allele frequency was 60% in control group and 72% in breast cancer patients. There was a significant association between A allele in -2548 position of LEPTIN gene and breast cancer susceptibility (OR: 1.8, 95% CI: 1.3-2.4, P<0.001). In the recessive effect of the A allele (comparison between AA vs. AG+GG), AA GENOTYPE in - 2548 region of LEPTIN promoter sequence was significantly increased the risk of breast cancer (OR=2.2, 95% CI: 1.5-3.4, P<0.001).Conclusion: It is concluded that A allele in the -2548 promoter region of LEPTIN gene may act as a recessive allele and increase the breast cancer risk.

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APA: Copy

ROSTAMI, SARA, KOHAN, LEILA, MOHAMMADIANPANAH, MOHAMMAD, & FEREIDUNI, FERESHTEH. (2014). ASSOCIATION BETWEEN G-2548A LEPTIN GENE POLYMORPHISM AND BREAST CANCER RISK. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 72(6), 360-366. SID. https://sid.ir/paper/38784/en

Vancouver: Copy

ROSTAMI SARA, KOHAN LEILA, MOHAMMADIANPANAH MOHAMMAD, FEREIDUNI FERESHTEH. ASSOCIATION BETWEEN G-2548A LEPTIN GENE POLYMORPHISM AND BREAST CANCER RISK. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2014;72(6):360-366. Available from: https://sid.ir/paper/38784/en

IEEE: Copy

SARA ROSTAMI, LEILA KOHAN, MOHAMMAD MOHAMMADIANPANAH, and FERESHTEH FEREIDUNI, “ASSOCIATION BETWEEN G-2548A LEPTIN GENE POLYMORPHISM AND BREAST CANCER RISK,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 72, no. 6, pp. 360–366, 2014, [Online]. Available: https://sid.ir/paper/38784/en

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