مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

1,221
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

AMNIOTIC MEMBRANE SEEDED WITH MESENCHYMAL ADIPOSE-DERIVED STEM CELL FOR COVERAGE OF WOUND IN THIRD DEGREE BURN: AN EXPERIMENTAL STUDY

Pages

  367-378

Abstract

 Background: STEM CELLs are applied in the treatment of wide range of diseases and can be separated from different tissues of the body. These cells can treat diseases by cytokine and growth factor secretion and also cell differentiation. BURN WOUND is a challenging problem of reconstructive surgery and STEM CELLs may help WOUND healing process. We designed this study to evaluate the beneficial effect of fat derived STEM CELLs for coverage of 3rd degree BURN WOUND.Methods: This study was experimental and has been done in BURN Research Center of Iran University of Medical Sciences during January 2012 to April 2013. Thirty rats randomly divided to three equal groups. Inguinal fat of 10 rats (one group) were used for preparation of autologous adipose-derived mesenchymal STEM CELLs. Acellular AMNION was used as a scaffold for STEM CELL transfer. Each of the thirty rats had been exposed to a cm deep 3rd degree BURN on back area.24 hours after surgery, the WOUND was excised and it had been covered by three methods: conventional dressing in the first group, acellular AMNION in the second group and acellular AMNION seeded with adipose-derived STEM CELL in the third group. The rate of WOUND healing and pathologic characteristics was compared in all three groups.Results: Healing rate and decrease in WOUNDs size was significantly better in acellular AMNION seeded with adipose- derived STEM CELLs compared with other two groups at 3rd and 15th days after surgery P<0.01.Also in histopathology examination, fibroplasia and neovascularization of WOUNDs were significantly better in STEM CELLs group than the other two groups P<0.001.Conclusion: Acellular AMNION seeded with adipose-derived STEM CELL can result in faster WOUND healing and better histopathology characteristic. The AMNION as a scaffold and the fat derived STEM CELLs as healing accelerator are recommended for coverage of the 3rd degree BURN WOUNDs after excision and it may reduce the need for skin graft.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    FATEMI, MOHAMMAD JAVAD, KHAJERAHIMI, AMIR ASADOLLAH, NIKOUMARAM, BABAK, SAKHAEI, MARYAM, MOSTAFAVI, SHABNAM, ATASHI, AMIR, PEDRAM, MIRSEPEHR, AGHAYAN, SEYED HAMID REZA, ARAGHI, SHIRIN, SOLTANI, MAJID, & MOSSAHEBI MOHAMMADI, MAJID. (2014). AMNIOTIC MEMBRANE SEEDED WITH MESENCHYMAL ADIPOSE-DERIVED STEM CELL FOR COVERAGE OF WOUND IN THIRD DEGREE BURN: AN EXPERIMENTAL STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 72(6), 367-378. SID. https://sid.ir/paper/38788/en

    Vancouver: Copy

    FATEMI MOHAMMAD JAVAD, KHAJERAHIMI AMIR ASADOLLAH, NIKOUMARAM BABAK, SAKHAEI MARYAM, MOSTAFAVI SHABNAM, ATASHI AMIR, PEDRAM MIRSEPEHR, AGHAYAN SEYED HAMID REZA, ARAGHI SHIRIN, SOLTANI MAJID, MOSSAHEBI MOHAMMADI MAJID. AMNIOTIC MEMBRANE SEEDED WITH MESENCHYMAL ADIPOSE-DERIVED STEM CELL FOR COVERAGE OF WOUND IN THIRD DEGREE BURN: AN EXPERIMENTAL STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2014;72(6):367-378. Available from: https://sid.ir/paper/38788/en

    IEEE: Copy

    MOHAMMAD JAVAD FATEMI, AMIR ASADOLLAH KHAJERAHIMI, BABAK NIKOUMARAM, MARYAM SAKHAEI, SHABNAM MOSTAFAVI, AMIR ATASHI, MIRSEPEHR PEDRAM, SEYED HAMID REZA AGHAYAN, SHIRIN ARAGHI, MAJID SOLTANI, and MAJID MOSSAHEBI MOHAMMADI, “AMNIOTIC MEMBRANE SEEDED WITH MESENCHYMAL ADIPOSE-DERIVED STEM CELL FOR COVERAGE OF WOUND IN THIRD DEGREE BURN: AN EXPERIMENTAL STUDY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 72, no. 6, pp. 367–378, 2014, [Online]. Available: https://sid.ir/paper/38788/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top