THE EFFECT OF REBOXETINE IN THE TREATMENT OF DEPRESSION IN CHILDREN AND ADOLESCENTS

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TASHAKORI A.; ARABGOL F.; PANAGHI L.; DAVARI ASHTIANI R.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2007 | Volume:65 | Issue:8 Page(s): 40-48

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Title

THE EFFECT OF REBOXETINE IN THE TREATMENT OF DEPRESSION IN CHILDREN AND ADOLESCENTS

Author(s)

TASHAKORI A. | ARABGOL F. | PANAGHI L. | DAVARI ASHTIANI R. | Issue Writer Certificate

Keywords

CHILDREN AND ADOLESCENTSQ3

DEPRESSIONQ2

REBOXETINEQ3

TREATMENTQ3

Abstract

Background: Depressive disorders in CHILDREN AND ADOLESCENTS are chronic and highly morbid. Few studies are carried out on antidepressant drugs for depressed youths, especially specific noradrenergic agents. REBOXETINE is a selective norepinephrine reuptake inhibitor. This study was designed to evaluate the effect of REBOXETINE in childhood and adolescent DEPRESSION.Methods: Twenty patients of both genders, aged 7-17 years old, with major depressive or dysthymic disorders, as classified by the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), participated in an 8-week clinical trial before-after study of REBOXETINE. Clinical semistructured interviews, based on the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS), were carried out. Reboxtine was initiated at a dose of 1 mg/day and increased up to 6 mg/day. Patients were assessed for changes in: depressive symptoms using the Children’s DEPRESSION Inventory (CDI) and global functioning by the Children’s Global Assessment Scale (C-GAS). Side effect questionnaire was also administered.Results: There was a significant decrease in the ineffectiveness subscale (C factor) of CDI (p=0.006). Although the CDI scores decreased by 32.69%, this change was not significant (p=0.39). No significant change in C-GAS (p=0.2) was observed. Adverse effects were relatively mild to moderate and transient. The most common adverse effects were decreased appetite and sedation.Conclusions: REBOXETINE is relatively well tolerated and improves feelings of ineffectiveness among depressed CHILDREN AND ADOLESCENTS; however it does not improve all depressive symptoms. Double-blind, placebo and active comparator controlled studies and larger sample sizes are indicated.

Cites

PREDICTING OF DEPRESSION SYMPTOMS BY PERSONALITY TRAITS IN CHILDREN

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APA: Copy

TASHAKORI, A., ARABGOL, F., PANAGHI, L., & DAVARI ASHTIANI, R.. (2007). THE EFFECT OF REBOXETINE IN THE TREATMENT OF DEPRESSION IN CHILDREN AND ADOLESCENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 65(8), 40-48. SID. https://sid.ir/paper/38853/en

Vancouver: Copy

TASHAKORI A., ARABGOL F., PANAGHI L., DAVARI ASHTIANI R.. THE EFFECT OF REBOXETINE IN THE TREATMENT OF DEPRESSION IN CHILDREN AND ADOLESCENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;65(8):40-48. Available from: https://sid.ir/paper/38853/en

IEEE: Copy

A. TASHAKORI, F. ARABGOL, L. PANAGHI, and R. DAVARI ASHTIANI, “THE EFFECT OF REBOXETINE IN THE TREATMENT OF DEPRESSION IN CHILDREN AND ADOLESCENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 65, no. 8, pp. 40–48, 2007, [Online]. Available: https://sid.ir/paper/38853/en

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