ORAL PENBACTAM IN THE TREATMENT OF ACUTE BACTERIAL SINUSITIS: A RANDOMIZED CLINICAL TRIAL

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HASIBI M.; MOHRAZ M.; HAJI ABD ALBAGHI MAHBOUBEH; RASOULINEZHAD MEHRNAZ; BAYAT A.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2006 | Volume:64 | Issue:4 Page(s): 102-107

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Title

ORAL PENBACTAM IN THE TREATMENT OF ACUTE BACTERIAL SINUSITIS: A RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

PENBACTAMQ3

AMPICILLIN-SULBACTUMQ3

CO-AMOXICOLAVQ3

ACUTE BACTERIAL SINUSITISQ3

SULTAMICILLINQ3

Abstract

Background: ACUTE BACTERIAL SINUSITIS is one of the most common causes for antibacterial treatment.Oral PENBACTAM (ampicillin- sulbactum or SULTAMICILLIN) is a broad spectrum antibiotic and it has no significant side effect.To our knowledge, this is the first study in Iran in which, oral PENBACTAM has been prescribed for patients with ACUTE BACTERIAL SINUSITIS.Methods: A randomized clinical trial was performed on 44 outpatients diagnosed with ACUTE BACTERIAL SINUSITIS in Amir- Aalam Hospital from March 2003-2004 to August 2004. Patients were randomized in 2 group: 23 to oral PENBACTAM (375 mg twice daily), and 21 to oral CO-AMOXICOLAV (625 mg three times daily). Duration of treatment was 10 days for both groups.Results: Both groups showed a significant clinical improvement after 10 days of treatment. In the PENBACTAM group, 19 of 23 (86.36%) and in the CO-AMOXICOLAV group, 18 of 21 (85.71%) showed clinical improvement.In the PENBACTAM group, one patient (4.3 %) developed diarrhea and the medication was discontinued.Conclusion: Oral PENBACTAM is an effective and safe antibiotic in the treatment of ACUTE BACTERIAL SINUSITIS and could be used as an alternative medication for ACUTE BACTERIAL SINUSITIS.

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APA: Copy

HASIBI, M., MOHRAZ, M., HAJI ABD ALBAGHI, MAHBOUBEH, RASOULINEZHAD, MEHRNAZ, & BAYAT, A.. (2006). ORAL PENBACTAM IN THE TREATMENT OF ACUTE BACTERIAL SINUSITIS: A RANDOMIZED CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 64(4), 102-107. SID. https://sid.ir/paper/38949/en

Vancouver: Copy

HASIBI M., MOHRAZ M., HAJI ABD ALBAGHI MAHBOUBEH, RASOULINEZHAD MEHRNAZ, BAYAT A.. ORAL PENBACTAM IN THE TREATMENT OF ACUTE BACTERIAL SINUSITIS: A RANDOMIZED CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2006;64(4):102-107. Available from: https://sid.ir/paper/38949/en

IEEE: Copy

M. HASIBI, M. MOHRAZ, MAHBOUBEH HAJI ABD ALBAGHI, MEHRNAZ RASOULINEZHAD, and A. BAYAT, “ORAL PENBACTAM IN THE TREATMENT OF ACUTE BACTERIAL SINUSITIS: A RANDOMIZED CLINICAL TRIAL,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 64, no. 4, pp. 102–107, 2006, [Online]. Available: https://sid.ir/paper/38949/en

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