A COMPARING STUDY OF 10-DAY REGIMEN OF AMOXICILLIN-CLAVULANATE WITH 5-DAY REGIMEN OF AZITHROMYCIN FOR TREATMENT OF ACUTE BACTERIAL SINUSITIS

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ZANGANEH MEHRANGIZ; SHARIATI N.A.; YAZDAN YAR A.F.; JAMSHIDI MAHIN; FARHOUDI B.; ALIJANI MOHSEN

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2007 | Volume:11 | Issue:35 Page(s): 25-28

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Title

A COMPARING STUDY OF 10-DAY REGIMEN OF AMOXICILLIN-CLAVULANATE WITH 5-DAY REGIMEN OF AZITHROMYCIN FOR TREATMENT OF ACUTE BACTERIAL SINUSITIS

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Keywords

ACUTE BACTERIAL SINUSITISQ3

AZITHROMYCINQ3

CO-AMOXICLAVQ3

Abstract

Background and objective: ACUTE BACTERIAL SINUSITIS (ABS) is an acute infection of the paranasal sinuses and nose most commonly caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. In this study was compared the efficacy and safety of AZITHROMYCIN (AZM) regimen, to the efficacy and safety of an amoxicillin-clavulanate (AMC) regimen.Material and methods: A total of 80 subjects (male 60%,female 40% ,mean age 32.7 years) 8 years of age or older with clinical diagnosis of ABS of sinuses upon entry into the study. Diagnosis was confirmed by the presence of either purulent nasal discharge or facial pain and/or pressure and/or tightness & X rays positive of sinuses. These patients were treated by AZITHROMYCIN and coamoxiclave.Result: Clinical success rates were at the end of therapy (AZM-5, 37.5%; AMC, 72.5%). Subjects treated with AMC reported a higher incidence of treatment-related adverse events (17.5%) than AZM-5 (5%), P<0.001. Gastrointestinal discomfort was the most frequent treatment-related adverse effect.Conclusion: Result of this study demonstrated that AZM provides a better safety profile and better compliance than AMC for the treatment of ABS . Furture investigations of ABS treatment may require with longer duration or higher dose of AZM.

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APA: Copy

ZANGANEH, MEHRANGIZ, SHARIATI, N.A., YAZDAN YAR, A.F., JAMSHIDI, MAHIN, FARHOUDI, B., & ALIJANI, MOHSEN. (2007). A COMPARING STUDY OF 10-DAY REGIMEN OF AMOXICILLIN-CLAVULANATE WITH 5-DAY REGIMEN OF AZITHROMYCIN FOR TREATMENT OF ACUTE BACTERIAL SINUSITIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(35), 25-28. SID. https://sid.ir/paper/52925/en

Vancouver: Copy

ZANGANEH MEHRANGIZ, SHARIATI N.A., YAZDAN YAR A.F., JAMSHIDI MAHIN, FARHOUDI B., ALIJANI MOHSEN. A COMPARING STUDY OF 10-DAY REGIMEN OF AMOXICILLIN-CLAVULANATE WITH 5-DAY REGIMEN OF AZITHROMYCIN FOR TREATMENT OF ACUTE BACTERIAL SINUSITIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2007;11(35):25-28. Available from: https://sid.ir/paper/52925/en

IEEE: Copy

MEHRANGIZ ZANGANEH, N.A. SHARIATI, A.F. YAZDAN YAR, MAHIN JAMSHIDI, B. FARHOUDI, and MOHSEN ALIJANI, “A COMPARING STUDY OF 10-DAY REGIMEN OF AMOXICILLIN-CLAVULANATE WITH 5-DAY REGIMEN OF AZITHROMYCIN FOR TREATMENT OF ACUTE BACTERIAL SINUSITIS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 35, pp. 25–28, 2007, [Online]. Available: https://sid.ir/paper/52925/en

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