ANTI-INFLAMMATORY EFFECTS OF MORPHINE ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE MODEL OF ACUTE INFLAMMATION

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POURPAK Z.; ALE BOUYEH M.; AHMADIANI A.

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Journal: Tehran University Medical Journal Year:2002 | Volume:60 | Issue:4 Page(s): 262-276

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Title

ANTI-INFLAMMATORY EFFECTS OF MORPHINE ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE MODEL OF ACUTE INFLAMMATION

Author(s)

POURPAK Z. | ALE BOUYEH M. | AHMADIANI A. | Issue Writer Certificate

Keywords

MORPHINEQ4

CARRAGEENANQ4

ACUTE INFLAMATIONAQ4

MICEQ4

Abstract

Background: Using the systemic opioids in pain relief has been known during the history. Several evidences indicate that exogenous opioids such as MORPHINE can produce anti-nociceptive effects by interacting with local opioid receptors in peripheral inflamed tissues; In addition to analgesic effects of MORPHINE, less clear is potential anti-inflammatory effects of it. Materials and Methods: In the present study we examined effects of intra-peritoneal (Lp.) injection of MORPHINE (7mg/kg) on CARRAGEENAN (O.05ml, 3% WN in saline) induced paw edema in MICE. Results: CARRAGEENAN induced paw edema were measured by mercury plethysmometer and was maximal at hour 3 and pretreatment with MORPHINE could reduce the edema significantly. At the same time the serum levels of interleukin-l alpha (IL-1a) were increased. Pretreatment with naloxone (2&10 mg / kg, Lp.) at 45 min before and 165 min after CARRAGEENAN, respectively, blocked the effects of MORPHINE sulfate on edema in each groups. Pretreatment with naloxone abolished MORPHINE anti-inflammatory while decreased IL-la serum levels, significantly. Although, administration of anti mouse IL-la (7, 14&28 µg/mice, Lp.) abolished MORPHINE anti-inflammatory effects. Conclusion: These findings showed that increase in serum levels of IL-la play important roles in anti-inflammatory effect of MORPHINE. The results indicated that MORPHINE exert significant anti-inflammatory activity. Presumably, the anti inflammatory action of MORPHINE may be due to change on the cytokine production. And /or release by host immune system.

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APA: Copy

POURPAK, Z., ALE BOUYEH, M., & AHMADIANI, A.. (2002). ANTI-INFLAMMATORY EFFECTS OF MORPHINE ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE MODEL OF ACUTE INFLAMMATION . TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 60(4), 262-276. SID. https://sid.ir/paper/38980/en

Vancouver: Copy

POURPAK Z., ALE BOUYEH M., AHMADIANI A.. ANTI-INFLAMMATORY EFFECTS OF MORPHINE ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE MODEL OF ACUTE INFLAMMATION . TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2002;60(4):262-276. Available from: https://sid.ir/paper/38980/en

IEEE: Copy

Z. POURPAK, M. ALE BOUYEH, and A. AHMADIANI, “ANTI-INFLAMMATORY EFFECTS OF MORPHINE ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE MODEL OF ACUTE INFLAMMATION ,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 60, no. 4, pp. 262–276, 2002, [Online]. Available: https://sid.ir/paper/38980/en

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