STUDY THE EFFECTS OF MALVA SYLVESTRIS HYDRO-ALCOHOLIC EXTRACT ON THECARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT PAW

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ARZI ARDESHIR; NAZARIKHORASGANI ZAHRA; RAHMANI MOHAMMAD

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Journal: Jentashapir Journal of Cellular and Molecular Biology Year:2013 | Volume:4 | Issue:1 Page(s): 1-10

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Title

STUDY THE EFFECTS OF MALVA SYLVESTRIS HYDRO-ALCOHOLIC EXTRACT ON THECARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT PAW

Author(s)

ARZI ARDESHIR | NAZARIKHORASGANI ZAHRA | RAHMANI MOHAMMAD | Issue Writer Certificate

Keywords

MALVA SYLVESTRISQ3

ASPIRINQ3

CARRAGEENANQ3

INFLAMMATIONQ3

RATQ3

Abstract

Background: Using chemical drugs have often masses of damaged side effects Therefore, it is important to research about medicinal plants with anti-inflammation and fewer side effects. malvasylvestris has potential use as a medicinal plant. The aim of this study was to investigate the effect of MALVA SYLVESTRIS flowers hydroalcoholic extract on the CARRAGEENAN-induced inflammatory response using Wistar male RATs' paws. Methods: MALVA SYLVESTRIS flowers powder was macerated with 70%ethanol, and its extract prepared. Male Wistar RATs were divided into 6 groups of 10 animals each for following treatments: Malva extract (200, 400, 600 and 800 mg/kg), normal saline (5mg/kg) as negative control and ASPIRIN (300mg/kg) as a positive via IP. Thirty min later INFLAMMATION was induced by injection of 100μlcarrageenan (1%W/V) into the RAT's hind paw of RATs (SC). The inflamation response changes were inspected over 5 hours every hour, using plethysmometer.Results: The extract-treated (600, 800 mg/kg) showed considerable reduction in the RATs' paws inflamation when compared with control groop (p>0.05). But 200 and 400 mg/kg extract showed no considerable decrease in INFLAMMATION when comparied with control group (p<0.05). There was not significant differences between doses of 600 and 800 mg/kg of extract, therefore dose of 600 mg/kg was selected as the most favorable dose as anti-inflammation.Conclusion: These findings demonstrate that extract of M. sylvestis could accelerate reducing INFLAMMATION responses in RATs and supports its traditional and probably medicinal benefits use.

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APA: Copy

ARZI, ARDESHIR, NAZARIKHORASGANI, ZAHRA, & RAHMANI, MOHAMMAD. (2013). STUDY THE EFFECTS OF MALVA SYLVESTRIS HYDRO-ALCOHOLIC EXTRACT ON THECARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT PAW. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 4(1), 1-10. SID. https://sid.ir/paper/205758/en

Vancouver: Copy

ARZI ARDESHIR, NAZARIKHORASGANI ZAHRA, RAHMANI MOHAMMAD. STUDY THE EFFECTS OF MALVA SYLVESTRIS HYDRO-ALCOHOLIC EXTRACT ON THECARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT PAW. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2013;4(1):1-10. Available from: https://sid.ir/paper/205758/en

IEEE: Copy

ARDESHIR ARZI, ZAHRA NAZARIKHORASGANI, and MOHAMMAD RAHMANI, “STUDY THE EFFECTS OF MALVA SYLVESTRIS HYDRO-ALCOHOLIC EXTRACT ON THECARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT PAW,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 4, no. 1, pp. 1–10, 2013, [Online]. Available: https://sid.ir/paper/205758/en

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