Expression of miR-378 gene and measuring plasma levels of Q10 in infertile men with normal spermatogenesis pattern

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Torkashvand Soheyla; FOROUZESH FLORA; MOHAMADNIA ABDOLREZA

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2020 | Volume:23 | Issue:6 Page(s): 70-75

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Title

Expression of miR-378 gene and measuring plasma levels of Q10 in infertile men with normal spermatogenesis pattern

Author(s)

Torkashvand Soheyla | FOROUZESH FLORA | MOHAMADNIA ABDOLREZA | Issue Writer Certificate

Keywords

coenzymQ10Q1

Male InfertilityQ1

miR-378Q1

SpermatogenesisQ1

Abstract

Introduction: Infertility is one of the most important health-treatment problems in many societies. Recently, much attention has been paid to the role of miRNA in the pathway of Spermatogenesis. miR-378 plays an important role in regulating proliferation and differentiation in the Spermatogenesis pathway. Q10 is also an antioxidant that plays a role in protecting cells from oxygen free radicals. Insufficient amounts of coenzyme Q10 can be a major factor in failed Spermatogenesis. This study was performed with aim to evaluate the plasma level of coenzyme Q10 and its association with expression of miR-378 gene in infertile men with normal Spermatogenesis pattern. Methods: This case-control study was performed on 45 infertile and 45 healthy individuals as controls. Expression of miR-378 was determined by qRT-PCR and enzyme level was measured by ELISA method. Data was analyzed by SPSS software (version 20) and t-test. P<0. 05 was considered statistically significant. Results: The Results: of this study indicated that the titres of coenzyme Q10 were significantly lower in the infertility group than the healthy subjects. Also, in infertile individuals, the expression of the miR-378 gene was averagely 1. 196 ± 0. 020 times of healthy individuals; this increase was not statistically significant (p = 0. 45). Conclusion: In general, the change in coenzyme Q10 significantly reduced in the serum of patients compared to controls. Also, in infertile individuals, the expression of miR-378 increased compared to healthy ones, which was not statistically significant. These findings can be effective in Spermatogenesis of Male Infertility. However, perhaps better Results: may be achieved by increasing the number of samples.

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APA: Copy

Torkashvand, Soheyla, FOROUZESH, FLORA, & MOHAMADNIA, ABDOLREZA. (2020). Expression of miR-378 gene and measuring plasma levels of Q10 in infertile men with normal spermatogenesis pattern. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 23(6 ), 70-75. SID. https://sid.ir/paper/390117/en

Vancouver: Copy

Torkashvand Soheyla, FOROUZESH FLORA, MOHAMADNIA ABDOLREZA. Expression of miR-378 gene and measuring plasma levels of Q10 in infertile men with normal spermatogenesis pattern. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2020;23(6 ):70-75. Available from: https://sid.ir/paper/390117/en

IEEE: Copy

Soheyla Torkashvand, FLORA FOROUZESH, and ABDOLREZA MOHAMADNIA, “Expression of miR-378 gene and measuring plasma levels of Q10 in infertile men with normal spermatogenesis pattern,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 23, no. 6 , pp. 70–75, 2020, [Online]. Available: https://sid.ir/paper/390117/en

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