EFFECT OF PENTOXIFYLLINE ON SKIN BIOMECHANICAL INDICES IN ACUTE PHASE OF SKIN WOUND HEALING IN RAT

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BABAEI S.; TALEBI R.; DARABI M.R.; NAKHAEI M.R.; BAYAT M.; BAYAT P.; BAAZM M.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:16 | Issue:8 (77) Page(s): 0-0

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Title

EFFECT OF PENTOXIFYLLINE ON SKIN BIOMECHANICAL INDICES IN ACUTE PHASE OF SKIN WOUND HEALING IN RAT

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Keywords

PENTOXIFYLLINEQ2

RATSQ2

SKINQ2

WOUND HEALINGQ2

Abstract

Background: PENTOXIFYLLINE is a xanthine derivative that causes deduction of blood viscosity, improves peripheral blood flow and increases tissue oxygenation. In this study, considering special properties of this drug and in spite of undefined mechanism of its effect, the effect of PENTOXIFYLLINE on SKIN biomechanical indices in acute phase of SKIN WOUND HEALING in rat is evaluated.Materials and methods: In this experimental study, 14 adult Wistar RATS were divided into two groups of experimental (n=7) receiving 100mg/kg PENTOXIFYLLINE twice a day and control (n=7) receiving distilled water, intraperitoneal. Incisional wound with 20mm length in identical pattern were created on back SKIN of RATS. After 15 days, SKIN strips containing wound were excised and used to evaluate biomechanical indices, work up to maximum force-Nm and Tensile strength=Rm-N/mm2.Data were analyzed by SPSS software and by T-Test.Results: According to biomechanical test findings, PENTOXIFYLLINE administration causes improvement in biomechanical indices of SKIN after 15 days of administration. Discrepancy between SKIN biomechanical indices of experimental and control subgroups was significant (p<0.05).Conclusion: PENTOXIFYLLINE caused improvement in SKIN biomechanical indices and accelerated SKIN WOUND HEALING in experimental group.

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APA: Copy

BABAEI, S., TALEBI, R., DARABI, M.R., NAKHAEI, M.R., BAYAT, M., BAYAT, P., & BAAZM, M.. (2013). EFFECT OF PENTOXIFYLLINE ON SKIN BIOMECHANICAL INDICES IN ACUTE PHASE OF SKIN WOUND HEALING IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(8 (77)), 0-0. SID. https://sid.ir/paper/391190/en

Vancouver: Copy

BABAEI S., TALEBI R., DARABI M.R., NAKHAEI M.R., BAYAT M., BAYAT P., BAAZM M.. EFFECT OF PENTOXIFYLLINE ON SKIN BIOMECHANICAL INDICES IN ACUTE PHASE OF SKIN WOUND HEALING IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(8 (77)):0-0. Available from: https://sid.ir/paper/391190/en

IEEE: Copy

S. BABAEI, R. TALEBI, M.R. DARABI, M.R. NAKHAEI, M. BAYAT, P. BAYAT, and M. BAAZM, “EFFECT OF PENTOXIFYLLINE ON SKIN BIOMECHANICAL INDICES IN ACUTE PHASE OF SKIN WOUND HEALING IN RAT,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 8 (77), pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/391190/en

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