ACOMPARATIVE EVALUATION OF ACUTE STRESS AND CORTICOSTERONE ON THE PROCESS OF LEARNING AND EMOTIONAL MEMORY IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAFAEI A.A.; RASHIDY POUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2009 | Volume:67 | Issue:4 Page(s): 241-249

Download Full-Text

Persian Verion

View:

1,144

Download:

Cites:

Information Journal Paper

Title

ACOMPARATIVE EVALUATION OF ACUTE STRESS AND CORTICOSTERONE ON THE PROCESS OF LEARNING AND EMOTIONAL MEMORY IN RAT

Author(s)

VAFAEI A.A. | RASHIDY POUR A. | Issue Writer Certificate

Keywords

CORTICOSTERONEQ3

ACQUISITIONQ3

CONSOLIDATIONQ3

RETRIEVALQ3

MEMORYQ3

PASSIVE AVOIDANCE LEARNINGQ3

Abstract

Background: Previous studies suggested that stressful events that release Glucocorticoid from adrenal cortex and also injection of agonists of glucocorticoids receptors probably affect emotional learning and MEMORY process and modulate them. The aim of this study was to determine the effects of acute stress and systemic injection of CORTICOSTERONE (as agonist of glucocorticoid receptors) on ACQUISITION (ACQ), CONSOLIDATION (CONS) and RETRIEVAL (RET) of emotional MEMORY in rat.Methods: In this experimental study we used 180 male Wistar rats (220-250). At the first rats was training in one trial inhibitory avoidance task. On the retention test given48 h after training, the latency to re-enter the dark compartment of the apparatus (Stepthrough latency, STL) and the time spent in light chamber (TLC) were recorded during 10min test. Intraperitoneal CORTICOSTERONE in doses of 0.5, 1 and 3mg/kg injected 30min before, immediately after instruction and30min before RETRIEVAL test. Also some groups received10min stressful stimulation by restrainer at the same time. At the end locomotor's activity was measured for all animals.Results: The data indicated that administration of CORTICOSTERONE 30min before ACQ (1mg/kg), and immediately after CONS (1, 3mg/kg) enhance and 30min before RET (1, 3mg/kg) impair emotional MEMORY (p<0.05). Acute stress impaired emotional MEMORY in all phases (p<0.05). Also acute stress and injection of CORTICOSTERONE have not significantly affect motor activity.Conclusions: These findings show that Glucocorticoid receptors in activation dependently plays an important role in modulation of emotional spatial MEMORY processes (ACQ, CONS and RET in new information) for emotional events and these effects varies in different phases.

Cites

No record.

References

No record.

Cite

APA: Copy

VAFAEI, A.A., & RASHIDY POUR, A.. (2009). ACOMPARATIVE EVALUATION OF ACUTE STRESS AND CORTICOSTERONE ON THE PROCESS OF LEARNING AND EMOTIONAL MEMORY IN RAT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 67(4), 241-249. SID. https://sid.ir/paper/39128/en

Vancouver: Copy

VAFAEI A.A., RASHIDY POUR A.. ACOMPARATIVE EVALUATION OF ACUTE STRESS AND CORTICOSTERONE ON THE PROCESS OF LEARNING AND EMOTIONAL MEMORY IN RAT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;67(4):241-249. Available from: https://sid.ir/paper/39128/en

IEEE: Copy

A.A. VAFAEI, and A. RASHIDY POUR, “ACOMPARATIVE EVALUATION OF ACUTE STRESS AND CORTICOSTERONE ON THE PROCESS OF LEARNING AND EMOTIONAL MEMORY IN RAT,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 67, no. 4, pp. 241–249, 2009, [Online]. Available: https://sid.ir/paper/39128/en

Related Journal Papers