THE EFFECTS OF VITAMIN-E ON OXIDATIVE STRESS AND METABOLIC IMBALANCE INDUCED BY ACUTE UNILATERAL URETERAL OBSTRUCTION IN ANAESTHETIZED RATS

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CHANGIZI ASHTIANI S.; SHID MOUSAVI SEYED MOSTAFA; HOSSEINKHANI S.; SHIRAZI MAHDI

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Journal: Tehran University Medical Journal Year:2008 | Volume:66 | Issue:9 Page(s): 617-624

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Title

THE EFFECTS OF VITAMIN-E ON OXIDATIVE STRESS AND METABOLIC IMBALANCE INDUCED BY ACUTE UNILATERAL URETERAL OBSTRUCTION IN ANAESTHETIZED RATS

Author(s)

CHANGIZI ASHTIANI S. | SHID MOUSAVI SEYED MOSTAFA | HOSSEINKHANI S. | SHIRAZI MAHDI | Issue Writer Certificate

Keywords

OBSTRUCTIVE NEPHROPATHYQ3

VITAMIN EQ3

STRESS OXIDATIVEQ2

METABOLISMQ2

RATQ3

Abstract

Background: OBSTRUCTIVE NEPHROPATHY has been associated with disorders in METABOLISM state and oxidative balance of kidney. STRESS OXIDATIVE play a key role in the pathophysiological processes of renal diseases. The objective of this study was to investigate effects of vitamin-E, as a powerful antioxidant, on renal oxidative stress and METABOLISM defect induced by 24-hr unilateral ureteral obstruction (UUO).Methods: Anesthetized male Sprague-Dawley RATs (n=10 in each group) were sterilely operated to occlude the left ureter. In UUO+NS, we had a single dose normal saline injection and in UUO+VitE and UUO+OO groups, D-α-tocopherol (50 mg/kg), the main component of vitamin-E, and its vehicle (Olive Oil), respectively, were twicely infused I.P. before and after UUO-induction. There were also sham-operated and control groups. 24-hr after of UUO-induction, both kidneys were removed and stored in -70°C. To determine METABOLISM condition, the levels of ATP and ADP; and to evaluate redox state, the levels of malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP) of kidneys were assessed.Results: The comparisons between UUO+NS and sham groups indicated that UUO increased MDA (p<0.001) and ADP (p<0.05), but decreased FRAP, and ATP/ADP RATio in obstructed kidney (all p<0.001). In UUO+VitE group, MDA and FRAP were equal to their levels in sham group, while ATP, ADP and ATP/ADP RATio were not different from those of UUO+NS group in obstructed kidney.Conclusion: Twenty four hour of UUO caused renal reduction in oxidative METABOLISM and elevations in reactive oxygen species; and administration of vitamin-E, although considerably ameliorated the oxidative stress, could not improve the defected METABOLISM.

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APA: Copy

CHANGIZI ASHTIANI, S., SHID MOUSAVI, SEYED MOSTAFA, HOSSEINKHANI, S., & SHIRAZI, MAHDI. (2008). THE EFFECTS OF VITAMIN-E ON OXIDATIVE STRESS AND METABOLIC IMBALANCE INDUCED BY ACUTE UNILATERAL URETERAL OBSTRUCTION IN ANAESTHETIZED RATS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(9), 617-624. SID. https://sid.ir/paper/39184/en

Vancouver: Copy

CHANGIZI ASHTIANI S., SHID MOUSAVI SEYED MOSTAFA, HOSSEINKHANI S., SHIRAZI MAHDI. THE EFFECTS OF VITAMIN-E ON OXIDATIVE STRESS AND METABOLIC IMBALANCE INDUCED BY ACUTE UNILATERAL URETERAL OBSTRUCTION IN ANAESTHETIZED RATS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(9):617-624. Available from: https://sid.ir/paper/39184/en

IEEE: Copy

S. CHANGIZI ASHTIANI, SEYED MOSTAFA SHID MOUSAVI, S. HOSSEINKHANI, and MAHDI SHIRAZI, “THE EFFECTS OF VITAMIN-E ON OXIDATIVE STRESS AND METABOLIC IMBALANCE INDUCED BY ACUTE UNILATERAL URETERAL OBSTRUCTION IN ANAESTHETIZED RATS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 9, pp. 617–624, 2008, [Online]. Available: https://sid.ir/paper/39184/en

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