EVALUATION OF SIDE EFFECTS OF ONDANSETRON IN PREGNANCY: A DESCRIPTIVE CASE-SERIES STUDY

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MIRZAMORADI MASOOMEH; HEIDAR ZAHRA; KIMIAEE PARICHEHR; SALEH MASOOMEH; ASHRAFIVAND SEPIDEH

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Journal: Tehran University Medical Journal Year:2015 | Volume:73 | Issue:1 Page(s): 55-59

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Title

EVALUATION OF SIDE EFFECTS OF ONDANSETRON IN PREGNANCY: A DESCRIPTIVE CASE-SERIES STUDY

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Keywords

HYPEREMESIS GRAVIDARUMQ2

ONDANSETRONQ2

PREGNANCY COMPLICATIONSQ1

Abstract

Background: ONDANSETRON is a 5-hydroxytryptamine receptor antagonist which is a highly effective antiemetic for postoperative and chemotherapy induced nausea and vomiting. It is an off-label drug to treat nausea and vomiting of pregnancy but available data about its safety is limited. In this study our purpose was to evaluate neonatal outcomes in women who received this treatment.Methods: This study is a descriptive retrospective case series study, included 22 pregnant women who treated with ONDANSETRON due to repeated nausea and vomiting unresponsive to our center's protocol, at Mahdiyeh Hospital, Tehran, Iran from May 2006 to September 2014. We investigated neonatal factors including: gestational age at birth, stillbirth, neonatal birth weight, apgar score, need to NICU admission and major birth defects.Results: The outcomes of 22 pregnancies and 22 newborns are presented here. We had two twin pregnancies and two abortions. ONDANSETRON was initiated in 18 cases (72%) on average gestational age of 9 weeks, during organogenesis. In 8 cases (32%) ONDANSETRON continued till third trimester of pregnancy. In primary evaluation, all the patients had ketonuria, 15 cases (60%) had hypokalmia (K<3.5), 3 cases (12%) had abnormal TSH that all of them were hyperthyroidism and 5 cases (20%) had abnormal liver function test (LFT) Three patients (12%) had positive urine culture, one patient had hypercalcemia and one patient who was known a case of hypocalcemia had low serum calcium.The mean time of admission due to HYPEREMESIS GRAVIDARUM (HG) was 5 days (2- 10 sd=1.92). In this study we had only one preterm birth and the mean neonatal birth weight was 3110 gram, one newborn was low birth weight due to preterm birth. Finally none of newborns had low apgar score, no one needed to NICU admission and no congenital anomaly was seen in neonates.Conclusion: ONDANSETRON taken during pregnancy was not associated with increased risk of adverse fetal outcomes.

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APA: Copy

MIRZAMORADI, MASOOMEH, HEIDAR, ZAHRA, KIMIAEE, PARICHEHR, SALEH, MASOOMEH, & ASHRAFIVAND, SEPIDEH. (2015). EVALUATION OF SIDE EFFECTS OF ONDANSETRON IN PREGNANCY: A DESCRIPTIVE CASE-SERIES STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 73(1), 55-59. SID. https://sid.ir/paper/39249/en

Vancouver: Copy

MIRZAMORADI MASOOMEH, HEIDAR ZAHRA, KIMIAEE PARICHEHR, SALEH MASOOMEH, ASHRAFIVAND SEPIDEH. EVALUATION OF SIDE EFFECTS OF ONDANSETRON IN PREGNANCY: A DESCRIPTIVE CASE-SERIES STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2015;73(1):55-59. Available from: https://sid.ir/paper/39249/en

IEEE: Copy

MASOOMEH MIRZAMORADI, ZAHRA HEIDAR, PARICHEHR KIMIAEE, MASOOMEH SALEH, and SEPIDEH ASHRAFIVAND, “EVALUATION OF SIDE EFFECTS OF ONDANSETRON IN PREGNANCY: A DESCRIPTIVE CASE-SERIES STUDY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 73, no. 1, pp. 55–59, 2015, [Online]. Available: https://sid.ir/paper/39249/en

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