RELATIONSHIP BETWEEN S ALLELES OF VACA GENE OF HELICOBACTER PYLORI AND GASTRODUODENAL DISEASES IN IRAN: A BRIEF REPORT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

LATIFI NAVID SAEID; MOHAMMADI SHIVA; ZAHRI SABER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2013 | Volume:71 | Issue:11 Page(s): 735-738

Download Full-Text

Persian Verion

View:

662

Download:

Cites:

Information Journal Paper

Title

RELATIONSHIP BETWEEN S ALLELES OF VACA GENE OF HELICOBACTER PYLORI AND GASTRODUODENAL DISEASES IN IRAN: A BRIEF REPORT

Author(s)

LATIFI NAVID SAEID | MOHAMMADI SHIVA | ZAHRI SABER | Issue Writer Certificate

Keywords

GASTRIC CANCERQ3

HELICOBACTER PYLORIQ3

PEPTIC ULCER DISEASEQ2

VACA S ALLELESQ2

Abstract

Background: HELICOBACTER PYLORI has been classified as the class I carcinogenic agent by world health organization. Colonization of the human stomach with H. pylori is a risk factor for gastroduodenal diseases. The secreted vacA toxin is an important H. pylori virulence factor that causes multiple alterations in gastric epithelial cells and T cells. Several families of vacA alleles have been described, and H. pylori strains containing certain vacA types (s1 and m1) are associated with an increased risk of gastric disease, compared to strains containing other vacA types (s2 and m2). We examined the association between H. pylori VACA S ALLELES and gastroduodenal diseases in Iran.Methods: A total of 149 H. pylori strains were obtained from patients with gastritis, peptic ulcer, and GASTRIC CANCER referring to endoscopy units of several cities in Iran. Biopsy culture and DNA extraction were performed and the frequency of VACA S ALLELES was investigated by using PCR amplification. Linear regression and binary logistic regression models were used to analyze the association between vacA (vacuolating cytotoxin A) s alleles and gastroduodenal diseases.Results: There was no significant association between the frequency of VACA S ALLELES and gastroduodenal diseases (gastritis or PEPTIC ULCER DISEASE and gastric adenocarcinoma (P>0.05)).Conclusion: It is proposed that the H. pylori vacA s1 genotype could not be considered as an important determinant of gastroduodenal diseases in Iranian population and probably if s1 allele is associated with other virulence alleles of this gene, it will cause diseases.

Cites

No record.

References

No record.

Cite

APA: Copy

LATIFI NAVID, SAEID, MOHAMMADI, SHIVA, & ZAHRI, SABER. (2013). RELATIONSHIP BETWEEN S ALLELES OF VACA GENE OF HELICOBACTER PYLORI AND GASTRODUODENAL DISEASES IN IRAN: A BRIEF REPORT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 71(11), 735-738. SID. https://sid.ir/paper/39256/en

Vancouver: Copy

LATIFI NAVID SAEID, MOHAMMADI SHIVA, ZAHRI SABER. RELATIONSHIP BETWEEN S ALLELES OF VACA GENE OF HELICOBACTER PYLORI AND GASTRODUODENAL DISEASES IN IRAN: A BRIEF REPORT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2013;71(11):735-738. Available from: https://sid.ir/paper/39256/en

IEEE: Copy

SAEID LATIFI NAVID, SHIVA MOHAMMADI, and SABER ZAHRI, “RELATIONSHIP BETWEEN S ALLELES OF VACA GENE OF HELICOBACTER PYLORI AND GASTRODUODENAL DISEASES IN IRAN: A BRIEF REPORT,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 71, no. 11, pp. 735–738, 2013, [Online]. Available: https://sid.ir/paper/39256/en

Related Journal Papers