The Effect of 6 Weeks Aerobic Training on Insulin Resistance, Nitric Oxide and Some Lipid Profiles of Type 2 Diabetic Male Rats

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MALEKSHAHI NIA HAMID; Dehkhoda Mohammad Reza; AHANGARPOUR AKRAM; RAJABI HAMID

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Title

The Effect of 6 Weeks Aerobic Training on Insulin Resistance, Nitric Oxide and Some Lipid Profiles of Type 2 Diabetic Male Rats

Author(s)

MALEKSHAHI NIA HAMID | Dehkhoda Mohammad Reza | AHANGARPOUR AKRAM | RAJABI HAMID | Issue Writer Certificate

Keywords

Aerobic ExerciseQ1

Insulin ResistanceQ1

Nitric OxideQ2

Lipid profilesQ1

DiabetesQ2

Abstract

Background and Objectives: Diabetes is one of the most important metabolic diseases can lead to endothelial dysfunction. Appropriate sport activity is recommended as a nonpharmacological option for control of its complications. The purpose of this study was to investigate the effect of continuous Aerobic Exercise on serum Nitric Oxide levels, Insulin Resistance, and some Lipid profiles in diabetic male rats. Subjects and Methods: We randomly divided 60 male Wistar rats (200± 20) into 6 groups of 10 rats per group: nondiabetic control, sham, aerobic, aerobic+salin, diabetic, diabetic-aerobic. Diabetes was induced by intra-peritoneal injection of streptozotocinnicotinamide. The rats were put into treadmill training for 6 weeks and 5 sessions/week. The rats were killed 48 h after the last training session and the levels of glucose, insulin, NO, HOMA-IR, LDL, HDL, TG and cholesterol were measured. One-way ANOVA and post hoc Tukey’ s test was used for statistical analysis (P<0. 05). Results: Diabetes increased the levels of glucose and HOMA-IR, but significantly reduced insulin and NO levels. After 6 weeks of aerobic training, glucose and Insulin Resistance decreased and Nitric Oxide levels increased compared with the Diabetes group. But there was no effect on the level of insulin serum level. Furthermore, a 6-week aerobic training did not have a significant effect on lipid factors among all groups (P<0. 05). Conclusion: It seems that aerobic training has a protective effect on vascular diseases in diabetic patients.

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APA: Copy

MALEKSHAHI NIA, HAMID, Dehkhoda, Mohammad Reza, AHANGARPOUR, AKRAM, & RAJABI, HAMID. (2018). The Effect of 6 Weeks Aerobic Training on Insulin Resistance, Nitric Oxide and Some Lipid Profiles of Type 2 Diabetic Male Rats. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(4 ), 401-413. SID. https://sid.ir/paper/392605/en

Vancouver: Copy

MALEKSHAHI NIA HAMID, Dehkhoda Mohammad Reza, AHANGARPOUR AKRAM, RAJABI HAMID. The Effect of 6 Weeks Aerobic Training on Insulin Resistance, Nitric Oxide and Some Lipid Profiles of Type 2 Diabetic Male Rats. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(4 ):401-413. Available from: https://sid.ir/paper/392605/en

IEEE: Copy

HAMID MALEKSHAHI NIA, Mohammad Reza Dehkhoda, AKRAM AHANGARPOUR, and HAMID RAJABI, “The Effect of 6 Weeks Aerobic Training on Insulin Resistance, Nitric Oxide and Some Lipid Profiles of Type 2 Diabetic Male Rats,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 4 , pp. 401–413, 2018, [Online]. Available: https://sid.ir/paper/392605/en

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