Stereological Study of the Protective Effect of Alpha-Lipoic Acid on Kidney Tissue following Toxicity with Silver Nanoparticles in NMRI Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARIATZADEH S.M.A.; GOUDARZI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:28 | Issue:4 Page(s): 100-112

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

374

Download:

Cites:

Information Journal Paper

Title

Stereological Study of the Protective Effect of Alpha-Lipoic Acid on Kidney Tissue following Toxicity with Silver Nanoparticles in NMRI Mice

Author(s)

SHARIATZADEH S.M.A. | GOUDARZI M. | Issue Writer Certificate

Keywords

Alpha lipoic acidQ1

KidneyQ1

NMRI MiceQ1

Silver nanoparticlesQ3

StereologyQ1

Abstract

Introduction: Today, with the advancements in technology and the use of Silver nanoparticles (AgNPs)in various products, serious concerns have been raised about the use of this substance. This study aimed to determine the effect of Alpha lipoic acid(ALA) as a potent antioxidant against the toxicity of AgNPs on Kidney tissue of NMRI Mice. Materials & Methods: In this experimental study, 24 adult male NMRI Mice with a mean weight of 36± 2 g were randomly allocated into four groups of control, AgNPs (500 mg/kg/day), ALA (100 mg/kg/day), and AgNPs+ALA. Subsequently, they were treated orally for 35 days and sacrificed. The left Kidney was taken out, fixed, sectioned, processed, and stained using the hematoxylin-eosin method. Following that, the biochemical and stereological parameters of the Kidney, such as the volume calculation of its various components were measured in this study. The data were analyzed in SPSS software (version 16). Ethics code: P/2/97s3113 Findings: In this study, there was a significant increase in the mean volume of the renal corpuscle (P<0. 005), glomerulus (P<0. 001), Taft (P<0. 001), and Bowman capsule membrane (P<0. 001); however, a significant decrease was observed in the mean total volume of Bowman capsule space (P<0. 001) and proximal tubule lumen volume (P<0. 05) in the AgNPs group, compared to the control group. The level of urea and malondialdehyde (P<0. 001) was increased in the AgNPs group, compared to the control group. In addition, total antioxidant capacity (P<0. 001) showed a significant decrease. Discussions & Conclusions: The ALA has a protective role in ameliorating Kidney damage caused by Silver nanoparticles.

Cites

No record.

References

Exposure to inorganic nanoparticles routes of entry immune response biodistribution and in vitro in vivo toxicity evaluation

Cite

APA: Copy

SHARIATZADEH, S.M.A., & GOUDARZI, M.. (2020). Stereological Study of the Protective Effect of Alpha-Lipoic Acid on Kidney Tissue following Toxicity with Silver Nanoparticles in NMRI Mice. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 28(4 ), 100-112. SID. https://sid.ir/paper/392619/en

Vancouver: Copy

SHARIATZADEH S.M.A., GOUDARZI M.. Stereological Study of the Protective Effect of Alpha-Lipoic Acid on Kidney Tissue following Toxicity with Silver Nanoparticles in NMRI Mice. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(4 ):100-112. Available from: https://sid.ir/paper/392619/en

IEEE: Copy

S.M.A. SHARIATZADEH, and M. GOUDARZI, “Stereological Study of the Protective Effect of Alpha-Lipoic Acid on Kidney Tissue following Toxicity with Silver Nanoparticles in NMRI Mice,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 4 , pp. 100–112, 2020, [Online]. Available: https://sid.ir/paper/392619/en

Related Journal Papers