FERTILITY PRESERVATION IN YOUNG WOMEN WITH ENDOMETRIAL CARCINOMA; REPORT OF THREE CASES

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MOUSAVI A.S.; BEHTASH N.; KARIMI ZARCHI M.; MODARES GILANI M.; GHAEM MAGHAMI FATEMEH

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Journal: Tehran University Medical Journal Year:2007 | Volume:65 | Issue:2 Page(s): 82-87

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Title

FERTILITY PRESERVATION IN YOUNG WOMEN WITH ENDOMETRIAL CARCINOMA; REPORT OF THREE CASES

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Keywords

ENDOMETRIAL CANCERQ2

CONSERVATIVE MANAGEMENTQ2

INFERTILITYQ3

Abstract

Background: Although ENDOMETRIAL CANCER is primarily a disease of the postmenopausal female, 25% of patients are premenopausal, with 3-5% in women 40 years old or younger. The younger group of women with endometrial carcinoma is frequently nulligravid with a history of INFERTILITY, and a strong desire to preserve fertility. This may pose a therapeutic dilemma for both patients and treating physician.Case report: We reported 3 young patients with atypical; complex hyperplasia or early stage ENDOMETRIAL CANCER that treated with conservative hormonal therapy.Conclusion: Medical treatment of young patients with endometrial carcinoma and complex atypical hyperplasia who wish to preserve fertility is a reasonable and appealing option. A comprehensive evaluation prior to counseling the patient should include A complete history and physical examination. A formal D&C with review of history with an experienced gyn-onc pathologist. Evaluation of the pelvic and abdomen preferably with contrast-enhanced MRI or transvaginal ultrasound. In patients found to have a clinical stage I grade I tumor and who want to preserve fertility, thorough counseling include risks and benefits, and explanation that the data is partial and incomplete due to the lack of appropriate controlled studies is mandatory. In patients considered for medical treatment, a high dose progestin regimen should be started with endometrial sampling every 3 months until complete regression of the tumor is documented. Although most responses are long standing, there is a small risk of progression during or after cessation of progestin therapy.

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APA: Copy

MOUSAVI, A.S., BEHTASH, N., MODARES GILANI, M., GHAEM MAGHAMI, FATEMEH, & KARIMI ZARCHI, M.. (2007). FERTILITY PRESERVATION IN YOUNG WOMEN WITH ENDOMETRIAL CARCINOMA; REPORT OF THREE CASES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 65(2), 82-87. SID. https://sid.ir/paper/39330/en

Vancouver: Copy

MOUSAVI A.S., BEHTASH N., MODARES GILANI M., GHAEM MAGHAMI FATEMEH, KARIMI ZARCHI M.. FERTILITY PRESERVATION IN YOUNG WOMEN WITH ENDOMETRIAL CARCINOMA; REPORT OF THREE CASES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;65(2):82-87. Available from: https://sid.ir/paper/39330/en

IEEE: Copy

A.S. MOUSAVI, N. BEHTASH, M. MODARES GILANI, FATEMEH GHAEM MAGHAMI, and M. KARIMI ZARCHI, “FERTILITY PRESERVATION IN YOUNG WOMEN WITH ENDOMETRIAL CARCINOMA; REPORT OF THREE CASES,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 65, no. 2, pp. 82–87, 2007, [Online]. Available: https://sid.ir/paper/39330/en

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