RELATIONSHIP OF SERUM MAGNESIUM LEVELS AND OTHER METABOLIC INDICES IN RENAL TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE

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AHMADI F.L.; NASERI ROZITA; LESANPEZESHKI M.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2008 | Volume:66 | Issue:7 Page(s): 492-497

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Title

RELATIONSHIP OF SERUM MAGNESIUM LEVELS AND OTHER METABOLIC INDICES IN RENAL TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE

Author(s)

AHMADI F.L. | NASERI ROZITA | LESANPEZESHKI M. | Issue Writer Certificate

Keywords

CYCLOSPORINEQ3

HYPOMAGNESAEMIAQ3

RENAL TRANSPLANTATIONQ3

HYPERLIPIDEMIAQ3

HYPERURICEMIAQ3

Abstract

Background: CYCLOSPORINE is one of the main immunosuppressors used for renal transplant recipients, and is given to prevent transplant rejection. Although the drug increases the survival of patients and grafted organs, it has some side effects independent of its effect on the immune system that are usually ignored. In this study, we evaluate the effect of CYCLOSPORINE on serum Mg levels and metabolic side effects in renal graft patients.Methods: In this study, we followed 157 renal transplant recipients (62 females and 95 males) who were being treated with CYCLOSPORINE at a private clinic to prevent transplant rejection. The patients were first physically examined and then blood samples were obtained in order to measure levels of CYCLOSPORINE, Mg, creatinine, fasting blood sugar, lipids, calcium, phosphorus, and uric acid levels. We then analyzed the data for correlations between serum Mg levels, CYCLOSPORINE and other metabolic complications.Results: The mean levels of Mg and CYCLOSPORINE were 196±0.31 mg/dl and 371±192 mg/dl, respectively. Hypomagnesemia was detected in 16 patients (10.2%).There was a significant negative correlation (p<0.05) between levels of Mg and CYCLOSPORINE levels (r=-0.53), serum creatinine (r=-0.61), plasma LDL (r=-0.3), fasting blood sugar (r=-0.60) and uric acid (r=-0.36), and no correlation (p>0.05) between levels of Mg and calcium (r=0.2), phosphorus (r=-0.01), triglycerides (r=0.06) and HDL (r=-0.08). Mean levels of CYCLOSPORINE, creatinine, LDL, fasting blood sugar and uric acid in patients with hypomagnesemia were significantly different from those patients with normal serum Mg levels (p<0.05). There was no significant difference between the two groups with regard to mean total cholesterol, HDL, calcium and phosphorus (p>0.05).Conclusion: According to the results of this and previous studies, there is a significant correlation between CYCLOSPORINE levels and hypomagnesemia as well as other biomedical complications secondary to hypomagnesemia. Therefore, we recommend routine serum Mg determination and greater attention to hypomagnesemic patients to prevent further complications.

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APA: Copy

AHMADI, F.L., NASERI, ROZITA, & LESANPEZESHKI, M.. (2008). RELATIONSHIP OF SERUM MAGNESIUM LEVELS AND OTHER METABOLIC INDICES IN RENAL TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(7), 492-497. SID. https://sid.ir/paper/39377/en

Vancouver: Copy

AHMADI F.L., NASERI ROZITA, LESANPEZESHKI M.. RELATIONSHIP OF SERUM MAGNESIUM LEVELS AND OTHER METABOLIC INDICES IN RENAL TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(7):492-497. Available from: https://sid.ir/paper/39377/en

IEEE: Copy

F.L. AHMADI, ROZITA NASERI, and M. LESANPEZESHKI, “RELATIONSHIP OF SERUM MAGNESIUM LEVELS AND OTHER METABOLIC INDICES IN RENAL TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 7, pp. 492–497, 2008, [Online]. Available: https://sid.ir/paper/39377/en

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